Methods and compositions for the treatment of cancers, such as melanomas and gliomas
OwnerSeth J. Orlow, Ming Cheninventors
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Abstract
A method of potentiating the efficacy of an antineoplastic agent such as temozolomide, comprises the administration of an antifolate agent as defined herein. Also disclosed are compositions, including pharmaceutical compositions, comprising the antineoplastic agent and an antifolate agent, and the use of such compounds and compositions thereof to treat a variety of cancers, such as melanoma. Unit dosage forms and kits are also contemplated and disclosed.
Claims42
A method for treating cancer comprising administering to a cancer patient a combination of temozolomide and an antifolate agent, wherein the antifolate agent is capable of crossing the blood-brain barrier.
A method for increasing the efficacy of temozolomide in the treatment of cancer comprising administering to a patient an effective amount of temozolomide in combination with an antifolate agent, wherein the antifolate agent is capable of crossing the blood-brain barrier.
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A method for treating advanced cancer sensitive to the combination below in patients in need of such treatment comprising administering temozolomide and an antifolate agent, wherein the antifolate agent is capable of crossing the blood-brain barrier.
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Dependencies are inferred from the claim text.