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AssigneeThe United States of America, as represented by the Secretary, Dept. of Health and Human Services
InventorsAlan T. Remaley, Stephen J. Demosky, John A. Stonik, Marcele J.A. Amar, Edward B. Neufeld, Bryan H. Brewer, Fairwell Thomas
Estimating the term…
Disclosed herein are peptides or peptide analogs with multiple amphipathic α-helical domains that promote lipid efflux from cells via an ABCA1-dependent pathway. Also provided herein are methods of using multi-domain amphipathic α-helical peptides or peptide analogs to treat or inhibit dyslipidemic disorders. Methods for identifying non-cytotoxic peptides that promote ABCA1-dependent lipid efflux from cells are also disclosed herein.
An isolated nucleic acid molecule encoding a peptide or peptide analog comprising an amino acid sequence as set forth in SEQ ID NO:
Dependencies are inferred from the claim text.