High-affinity antagonists of elr-cxc chemokines
AssigneeUniversity of Saskatchewan
InventorJohn R. Gordon
Life of this patent
Estimating the term…
Abstract
The present invention provides novel polypeptide sequences, methods for production thereof and uses thereof for novel ELR-CXC chemokine receptor agonists and antagonists.
Claims50
An isolated or purified peptide comprising an amino acid sequence of:
- X1ELRCXCIRX XSXPFXPKXI XEXXXIXSPP HCXNXEIIVK
- LXXGXEXCLX PXXXWVQXXV XXFXKXXEXX2X3X4
- wherein X1, X2, X3 and X4 are independently 0-10 amino acid residues and X is any amino acid.
An isolated or purified peptide comprising an amino acid sequence of:
- (SEQ ID No. 43)
- X1ELRCX6CIRX10X11SX13PFX16PKX19I X21EX23X24X25IX27
- SPPHCX33NX35EIIVK LX42X43GX45EX47CLX50 PX52X53X54W
- VQX58X59VX61X62FX64KX66X67EX69X70X71X72
- wherein:
- X1, X70, X71 and X72 are independently 0-10 amino acids;
- and
- X6, X10, X11, X13, X16, X19, X21, X23, X24, X25, X27, X33, X35, X42, X43, X45, X47, X50, X52, X53, X54, X58, X59, X61, X62, X64, X66, X67 and X69 are each independently selected from the group consisting of:
- A, D, E, F, G, H, I, K, L, M, N, P, Q, R, S, T, V and Y.
An isolated or purified peptide comprising an amino acid sequence of:
- (SEQ ID No. 4)
- X1ELRCX6CIRX10X11SX13PFX16PKX19I X21EX23X24X25IX27
- SPPHCX33NX35EIIVK LX42X43GX45EX47CLX50 PX52X53X54W
- VQX58X59VX61X62FX64KX66X67EX69X70X71X72
- wherein
- X1 is 0-10 amino acids;
- X6 is Q, E or L;
- X10 is T or I;
- X11 is H or Y;
- X13 is T or K;
- X16 is H or N;
- X19 is F or Y or L;
- X21 is K or R;
- X23 is L or M;
- X24 is R or T;
- X25 is V or A;
- X27 is D or E;
- X33 is V or A or E;
- X35 is T or S;
- X42 is S or V or T or F;
- X43 is D or N;
- X45 is R or A or N or K or D;
- X47 is L or V;
- X50 is D or N;
- X52 is K or H;
- X53 is E or Q or T;
- X54 is P or N or K;
- X58 is R or K or I;
- X59 is V or I;
- X61 is E or Q;
- X62 is K or I or V or A;
- X64 is L or V;
- X66 is R or K;
- X67 is A or T;
- X69 is S or N or K or G;
- X70 is Q or S or K or deleted;
- X71 is N or D or deleted;
- and
- X72 is P or A or S or deleted.
An isolated peptide consisting essentially of an amino acid sequence as set forth in any one of SEQ ID No. 10-41.
An isolated polynucleotide sequence comprising a nucleotide sequence encoding an amino acid sequence of:
- X1ELRCXCIRX XSXPFXPKXI XEXXXIXSPP HCXNXEIIVK
- LXXGXEXCLX PXXXWVQXXV XXFXKXXEXX2X3X4
- wherein X1, X2, X3 and X4 are independently 0-10 amino acid residues and X is any amino acid.
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Dependencies are inferred from the claim text.