Compositions and Methods for Inducing Hair Growth

A method of inducing hair growth and/or reducing or preventing hair loss, the method comprising administering to a subject in need thereof a therapeutically effective amount of at least one tellurium-containing compound having general Formula IV:

• wherein:
• each of m and n is independently an integer from 0 to 3;
• and
• each of R15-R22 is independently selected from the group consisting of hydrogen, hydroxyalkyl, hydroxy, thiohydroxy, alkyl, alkenyl, alkynyl, alkoxy, thioalkoxy, halogen, haloalkyl, carboxy, carbonyl, alkylcarbonylalkyl, carboxyalkyl, acyl, amido, cyano, N-monoalkylamidoalkyl, N,N-dialkylamidoalkyl, cyanoalkyl, alkoxyalkyl, carbamyl, cycloalkyl, heteroalicyclic, sulfonyl, sulfinyl, sulfate, amine, aryl, heteroaryl, phosphate, phosphonate and sulfoneamido.

A pharmaceutical composition, identified for use in inducing hair growth and/or reducing or preventing hair loss in a subject in need thereof, the composition comprising a therapeutically effective amount of at least one tellurium-containing compound having general Formula IV:

• wherein:
• each of t, u and v is independently 0 or 1;
• each of m and n is independently an integer from 0 to 3;
• Y is selected from the group consisting of ammonium, phosphonium, potassium, sodium and lithium;
• X is a halogen atom;
• and
• each of R1-R22 is independently selected from the group consisting of hydrogen, hydroxyalkyl, hydroxy, thiohydroxy, alkyl, alkenyl, alkynyl, alkoxy, thioalkoxy, halogen, haloalkyl, carboxy, carbonyl, alkylcarbonylalkyl, carboxyalkyl, acyl, amido, cyano, N-monoalkylamidoalkyl, N,N-dialkylamidoalkyl, cyanoalkyl, alkoxyalkyl, carbamyl, cycloalkyl, heteroalicyclic, sulfonyl, sulfinyl, sulfate, amine, aryl, heteroaryl, phosphate, phosphonate and sulfoneamido.