Crosslinked Gelatin Gel, Multilayered Structure, Carrier for Bioactive Factor, Preparation for Release of Bioactive Factor, and Their Production Methods
AssigneesNichiban Co., Ltd., Kyoto University
InventorsTomoyuki Ishiguro, Kenji Fukano, Yasuhiko Tabata
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Abstract
A multi-layer crosslinked gelatin gel structure having a layer structure that plural layers of crosslinked gelatin gel crosslinked by irradiating gelatin or a gelatin derivative with electron beam under an oxygen-containing atmosphere are arranged adjoiningly to each other, a preparation for release of a bioactive factor with the bioactive factor contained in the multi-layer crosslinked gelatin gel structure, and production processes thereof.
Claims20
A multi-layer crosslinked gelatin gel structure having a layer structure that plural layers of crosslinked gelatin gel crosslinked by irradiating gelatin or a gelatin derivative with electron beam under an oxygen-containing atmosphere are arranged adjoiningly to each other.
A process for producing a multi-layer crosslinked gelatin gel structure, which comprises as least the following Steps 1 and 2:
- Step 1 of applying an aqueous solution of gelatin or a gelatin derivative on to a support to form a coating layer, and then irradiating the coating layer with electron beam under an oxygen-containing atmosphere to form a first crosslinked gelatin gel layer;
- and
- Step 2 of applying an aqueous solution of gelatin or a gelatin derivative on to the first crosslinked gelatin gel layer to form a coating layer, and then irradiating the coating layer with the electron beam under the oxygen-containing atmosphere to form a second crosslinked gelatin gel layer.
Dependencies are inferred from the claim text.