Allograft bone composition having a gelatin binder
AssigneeMusculoskeletal Transplant Foundation
InventorsMoon Hae Sunwoo, Arthur A. Gertzman, Barbara L. Merboth
Life of this patent
Estimating the term…
Abstract
The invention is directed toward an osteoimplant for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing composition of demineralized allograft bone material mixed with an aqueous phosphate buffered gelatin which when lyophilized to remove water from the composition crosslinks the gelatin to form a solid structure and when rehydrated is flexible
Claims25
A sterile bone repair strip for application to a bone defect site to promote new bone growth at the site comprising a mixture of osteoinductive bone material in a carrier forming a composition, the bone material ranging from about 30% to about 50% of the weight of the composition of the strip and the carrier comprising a gelatin component dissolved in an buffered aqueous solution ranging from about 45% to about 60% of the weight of the composition of the strip and a hydrogel ranging from about 10% to about 20% of the composition, said composition being lyophilized to achieve a cross linking of the gelatin to obtain a structure stability and a pH ranging from about 6.5 to 7.5.
A sterile bone repair strip for application to a bone defect site to promote new bone growth at the site comprising a mixture of osteoinductive bone material in a carrier, the bone material ranging from about 40% to about 50% of the weight of the composition of the strip and the carrier comprising a gelatin component dissolved in an buffered aqueous solution ranging from 40% to about 60% of the weight of the composition of the strip and a hydrogel ranging from 10% to 20% of the weight of the strip, said strip being lyophilized to achieve a cross linking of the gelatin to obtain a structural stability and a pH ranging from about 6.5 to 7.5 and then rehydrated and placed in a sterile container.
A sterile bone repair strip for application to a bone defect site to promote new bone growth at the site comprising a mixture of osteoinductive bone material in a carrier, the bone material ranging from about 40% to about 50% of the weight of the composition and the carrier comprising a gelatin component dissolved in an buffered aqueous solution ranging from 40% to about 60% of the weight of the composition of the strip and a hyaluronan ranging from 10% to 20% of the composition of the strip, said strip being lyophilized to achieve a cross linking of the gelatin to obtain a structural stability and rehydrated to become flexible.
A sterile preformed bone implant for application to a bone defect site to promote new bone growth at the site comprising a new bone growth inducing partially demineralized lyophilized allograft bone particles with a residual calcium content of about 4 to 8% in an aqueous gelatin carrier which is lyophilized to remove water content leaving a cross linked gelatin bone structure having a structure stability which is maintained after application to said bone repair site with bone material ranging from about 40% to about 50% of the weight of the composition and the cross linked gelatin from about 7% to about 17% by weight of the composition and a hydrogel taken from a group consisting sodium hyaluronate and its derivatives, chitosan, sodium alginate, dextran, carboxymethylcellulose and hydroxypropylmethylcellulose ranging from 10% to 20% by weight of the composition prior to lyophilization.
A method of constructing a cross linked osteoinductive bone repair strip construct comprising the steps of:
- a. mixing osteoinductive bone material in an aqueous gelatin mixture containing a hydrogel to obtain a formulation;
- b. shaping the formulation to a predetermined shape;
- c. subjecting said formulation to lyophilization to remove at least 90% of the water from said aqueous gelatin mixture cross linking said gelatin and osteoinductive bone material contained therein to form a solid structure;
- and
- d. rehydrating the lyophilized shaped strip to a flexible condition.
Dependencies are inferred from the claim text.