Methods and compounds for mitigating pathogenic outbreaks using replikin count cycles
OwnerSamuel BOGOCH, Elenore S. BOGOCH +2inventors
InventorsSamuel BOGOCH, Elenore S. BOGOCH, Samuel Winston BOGOCH, Anne Elenore BORSANYI
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Abstract
The present invention provides methods of predicting increases in pathogenic virulence, morbidity, and/or mortality or expansion in pathogen populations within regions or into new regions by identifying cycles or ratios of increasing concentrations of a family of small peptides expressed in pathogens and provides compounds comprising the small peptides for treatment and prevention of pathogenic outbreaks.
Claims40
A method of predicting an expansion of a population of a first pathogen comprising:
- identifying at least one cycle of Replikin concentration in isolates of the first pathogen;
- and
- predicting that an expansion of the population of the first pathogen will take place after the occurrence of at least one rising portion of the at least one cycle of Replikin concentration, wherein the at least one cycle is cycle A.
A method of predicting an expansion of a population of a pathogen comprising:
- identifying at least one cycle of the Replikin concentration of a plurality of isolates of the pathogen or of a related pathogen,
- identifying a first peak in the Replikin concentration of a plurality of isolates of said pathogen within the at least one identified cycle at a first time point or time period, and
- predicting that an expansion of the population of a pathogen of the same species that is isolated at a second time point or time period will occur subsequent to the first time point or time period.
A method of predicting an expansion of a strain of pathogen comprising:
- determining a mean Replikin Count and a standard deviation of said mean Replikin Count for a plurality of isolates of a strain of pathogen for a first time period in a first geographic region;
- determining a Replikin Count of at least one isolate of the same or a related strain of pathogen from a second time period and/or second geographic region, wherein said second time period is different from said first time period and/or said second geographic region is different from said first geographic region, and wherein the second time period is not necessarily after the first time period;
- and
- predicting an expansion of said strain of pathogen isolated in said second time period and/or said second geographic region if the Replikin Count of said at least one isolate is greater than one standard deviation of the mean of the Replikin Count of the plurality of isolates isolated in said first time period and in said first geographic region.
A quantitative cyclic structure comprising Replikin peptide concentrations identified in a strain of microorganism through time, wherein said cyclic structure correlates in time with the expansion and/or contraction of a population of said strain of microorganism, the infectivity of said strain of microorganism, and/or the lethality of said strain of microorganism in its host.
Dependencies are inferred from the claim text.