Her-2/neu multi-peptide vaccine
AssigneeBio Life Science Forschungs-und Entwicklungsges m.b H
InventorsChristoph Zielinski, Otto Scheiner, Hubert Pehamberger, Heimo Breiteneder, Ursula Wiedermann
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Abstract
The present invention relates to a multi-peptide-multiepitop-vaccine against cancerous diseases associated with HER-2/neu oncogene, i.e. the vaccine comprises a specific combination of peptides presenting different amino acids sequences as occur in the extracellular domain of HER-2/neu protein.
Claims23
1-15. (canceled)
A vaccine against cancerous diseases associated with the HER-2/neu oncogene, wherein said vaccine comprises a mixture of at least three different peptides having a length of 9 to 30 amino acids and each sequence occurs in the extracellular domain of HER-2/neu protein or a functional variant thereof, wherein at least one peptide has the sequence set forth in amino acid 378 to amino acid 394 of the extracellular domain of HER-2/neu protein or a functional variant thereof, wherein at least one peptide has the sequence set forth in amino acid 545 to amino acid 560 of the extracellular domain of HER-2/neu protein or functional variants thereof, and wherein at least one peptide has the sequence set forth in amino acid 610 to amino acid 623 of the extracellular domain of HER-2/neu protein or a functional variants thereof.
A vaccine against cancerous diseases associated with the HER-2/neu oncogene, wherein said vaccine comprises a mixture of at least three different peptides having the following amino acid sequences:
- PESFDGDPASNTAPLQP;
- (SEQ ID NO:
- 1)
- RVLQGLPREYVNARHC;
- (SEQ ID NO:
- 2)
- and
- YMPIWKFPDEEGAC,
- (SEQ ID NO:
- 3)
- wherein at least one peptide is conjugated to a glycine linker and optionally, a C-terminal cysteine residue, and wherein the vaccine further comprises a carrier selected from the group consisting of keyhole limpet hemocyanin (KLH), tetanus toxoid (TT), B subunit of cholera toxin (CT, CTB), heat labile toxin (LT), B subunit (LTB) of E. coli, bacterial ghosts, liposome, chitosomes, virosomes, dendritic cells and lactic acid bacteria.
Dependencies are inferred from the claim text.