Stimulation of T Cells Against Self-Antigens Using CTLA-4 Blocking Agents
AssigneeThe Regents of the University of California
InventorsJames P. ALLISON, Andrea Van Elsas, Arthur A. Hurwitz
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Abstract
Stimulation of T cells to respond to self antigens is achieved through a blockade of CTLA-4 signaling. CTLA-4 blocking agents are combined with antigen preparations, either alone or with additional immune response stimulating agents, in costimulation strategies to break immune tolerance and stimulate an enhanced T-cell response against self antigens. This enhanced response is useful for the treatment of non-immunogenic and poorly-immunogenic tumors, as well as other medical conditions requiring selective tissue ablation.
Claims18
1-12. (canceled)
A method of treating established metastases in a mammalian host in need thereof comprising administering to said host a therapeutically effective amount of a CTLA-4 binding antibody or fragment thereof in combination with a self-antigen preparation.
Dependencies are inferred from the claim text.