Pancreatic Cancer Genes
OwnerGiulia C. Kennedyinventor
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Abstract
The present invention provides the art with the DNA coding sequences of polynucleotides that are up-or-down-regulated in cancer and dysplasia. These polynucleotides and encoded proteins or polypeptides can be used in the diagnosis or identification of cancer and dysplasia. Inhibitors of the up-regulated polynucleotides and proteins can decrease the abnormality of cancer and dysplasia. Enhancing the expression of down-regulated polynucleotides or introducing down-regulated proteins to cells can decrease the growth and/or abnormal characteristics of cancer and dysplasia.
Claims14
An antibody preparation which specifically binds to a polypeptide encoded by SEQ ID NO:
- 15.
A composition comprising an amount of an antibody which specifically binds the polypeptide encoded by SEQ ID NO:
- 15;
- and a pharmaceutically acceptable carrier, said amount effective to reduce the growth rate of contacted cancer cells by at least 50% as compared to a control.
A method for treating dysplasia in a patient having said dysplasia, said method comprising administering to said patient a composition comprising an amount of an antibody which specifically binds the polypeptide encoded by SEQ ID NO:
- 15;
- and a pharmaceutically acceptable carrier, said amount effective to reduce the growth rate of contacted dysplastic pancreatic cells by at least 50% as compared to a control.
A method for treating cancer in a patient having said cancer, said method comprising administering to said patient a composition comprising an amount of an antibody which specifically binds the polypeptide encoded by SEQ ID NO:
- 15;
- and a pharmaceutically acceptable carrier, said amount effective to reduce the growth rate of contacted pancreatic cancer cells by at least 50% as compared to a control.
Dependencies are inferred from the claim text.