Loading patent…
OwnerSalvatore Siena, Mauro Moroni +7inventors
InventorsSalvatore Siena, Mauro Moroni, Giovanna Marrapese, Andrea Sartore-Bianchi, Silvio Veronese, Marcello Gambacorta, Silvia Benvenuti, Federica Di Nicolantonio, Alberto Bardelli
Estimating the term…
The invention relates to an indidualized and personalized diagnosis and therapy of cancer based on specific molecular alterations which occur in specific tumor tissue of specific tumor patient populations. The therapy and diagnostic is based on the findings that proliferation and tumor growth of specific EGFR bearing tumor tissue expressing an amplified EGFR gene copy number may be abolished by anti-EGFR antibodies, while other individual molecular alterations such as mutations occurring in tumor tissues are unaffected by the same anti-EGFR antibody treatment.
An in vitro method for detecting and analyzing whether a patient suffering from a cancer, which overexpresses EGF receptor (EGFR), responds positively to the administration of an anti-EGFR antibody or an immunologically effective fragment thereof, the method comprising determining in vitro the EGFR gene copy number in a probe of tumor cells obtained from said patient and selecting said patient for administration with said anti-EFFR antibody if the tumor cells of said patient display an amplified copy number of the EGFR gene.
Use of an anti-EGFR antibody, or an immunologically effective fragment thereof, for the manufacture of a medicament for the treatment of cancer in a patient, wherein said cancer overexpresses EGFR and displays an amplified EGFR gene copy number.
Method for detecting and measuring in vitro the EGFR gene copy number of tumor tissue, which overexpresses EGFR, by using fluorescent in situ hybridization (FISH) in an assay for determining the response of a cancer patient to the administration with an anti-EGFR antibody.
A method of treating cancer which overexpresses EGFR and displays an amplified EGFR gene copy number comprising administering an anti-EGFR antibody, or an immunologically effective fragment thereof.
Dependencies are inferred from the claim text.