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US 2009/0269336 A1Published application
Anti-vegf monoclonal antibody
AssigneesTaiwan Liposome Co., Ltd., Tlc Biopharmaceuticals, Inc.
InventorsKeelung Hong, Luke S.S. Guo, Yun-Long Tseng, Hsiu-Li Song, Po-Chun Chang, Sheue-Fang Shih
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Abstract
The present invention provides novel monoclonal antibodies with a high binding affinity to all five isoforms of human VEGF.
Claims20
An anti-human vascular endothelial growth factor (VEGF) monoclonal antibody, wherein the antibody binds to an epitope containing the amino acid residues Asn100 to Lys107 in human VEGF (SEQ ID NO:
- 9) with a Kd value of no more than about 2×10−9 M, and wherein the antibody has a heavy chain variable region comprising one or more amino acid sequences selected from the group consisting of SEQ ID NOs:
- 1, 2 and 3, and a light chain variable region comprising one or more amino acid sequences selected from the group consisting of SEQ ID NOs:
- 4, 5 and 6.
Dependencies are inferred from the claim text.