Caspase-8 and inflammation, infection and wound healing
AssigneesHadasit Medical Research Services and Development Ltd., Yeda Research and Development Co. Ltd.
InventorsDavid Wallach, Rinai Abramovitch, Eitan Galun, Tehila Ben Moshe, Hila Barash
Life of this patent
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Abstract
The present invention relates to the regulatory role of caspase-8 in infection by intracellular pathogen, inflammation and wound healing
Claims26
-39. (canceled)
A method for preventing and/or treating inflammation of a tissue or organ, except skin, comprising administering to a patient in need a therapeutically effective amount of at least one agent selected from:
- (i) caspase-8 or a mutein, isoform, fused protein, functional derivative, active fraction, circularly permutated derivative or a salt thereof, (ii) an agent capable of up-regulating caspase-8 level and/or activity;
- and (iii) an inhibitor of a natural inhibitor of caspase-8 level and/or activity.
(canceled)
A method for treating an infection caused by an intracellular pathogen comprising administering to a patient in need a therapeutically effective amount of at least one agent selected from:
- (i) caspase-8 or a mutein, isoform, fused protein, functional derivative, active fraction, circularly permutated derivative or a salt thereof, (ii) an agent capable of up-regulating caspase-8 level and/or activity;
- and (iii) an inhibitor of a natural inhibitor of caspase-8 level and/or activity.
(canceled)
A method for facilitating or accelerating healing of a wounded or injured tissue or organ comprising administering to a patient in need a therapeutically effective amount an inhibitor of caspase-8 level and/or activity.
Dependencies are inferred from the claim text.