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OwnerHelena Edlund, Maria Öströminventors
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The invention relates to a method of forming pancreatic hormone-producing endocrine cells in vitro, wherein pancreatic stem cells are treated with one or more retinoids and/or retinoic acid in vitro and cultured. Especially the dorsal pancreatic bud is used and to the cells obtained by the method. Further, it relates to the use of the pancreatic hormone-producing endocrine cells, for the production of a pharmaceutical composition for transplantation and/or treatment of type 1 and type 2 diabetes. It also relates to a method for treatment of type 1 and type 2 diabetes by administrating the hormone-producing endocrine cells to individuals in need thereof. The invention also regards the use of one or more retinoids and/or retinoic acid for the differentiation, in vitro of pancreatic stem cells into pancreatic hormone-producing endocrine cells, such as glucagon producing cells, and in particular, insulin producing β-cells.
-12. (canceled)
A method of forming pancreatic hormone-producing endocrine cells in vitro, wherein embryonic pancreatic stem cells are treated with one or more retinoids and/or retinoic acid at a concentration of 10-200 nM in vitro and cultured.
Pancreatic hormone-producing endocrine cells, wherein said cells can be obtained by the method of forming pancreatic hormone-producing endocrine cells in vitro wherein pancreatic stem cells are treated with one or more retinoids and/or retinoic acid in vitro and cultured.
Use of pancreatic hormone-producing endocrine cells, obtainable by treating pancreatic stem cells with one or more retinoids and/or retinoic acid in vitro and culturing them, for the production of a pharmaceutical composition for transplantation and/or treatment of type 1 and type 2 diabetes.
A method for treatment of type 1 and type 2 diabetes wherein pancreatic hormone-producing endocrine cells, obtainable by treating pancreatic stem cells with one or more retinoids and/or retinoic acid in vitro and culturing them are transplanted into an individual in need thereof.
Use of one or more retinoids and/or retinoic acid for the differentiation, in vitro of pancreatic stem cells into pancreatic hormone-producing endocrine cells, such as glucagon producing cells, and in particular, insulin producing β-cells.
Dependencies are inferred from the claim text.