Process for the synthesis and purification of (4-methoxybutyl) (4-trifluoromethylphenyl) methanone

Process for the synthesis of (4-methoxybutyl)(4-trifluoromethylphenyl)methanone comprising:

• synthesising an organomagnesium specie CH3O(CH2)4MgX, where X is an halogen, reacting CH3O(CH2)4X with Mg in presence of a suitable initiator in a reaction medium formed by 2-methyl-tetrahydrofuran in admixture with organic solvents selected in the group consisting of polar aprotic ethereal solvents or apolar aprotic non chlorinated solvents;
• and
• synthesising and recovering said (4-methoxybutyl)(4-trifluoromethylphenyl)methanone by a coupling reaction of CH3O(CH2)4MgX by adding in the reaction mixture first obtained 4-trifluoromethylbenzonitrile or 4-trifluoromethylbenzoyl chloride dissolved in the same organic solvents of the first step, treating the mixture reaction obtained with aqueous acidic diluted solutions, separating the organic layer, and concentrating the same to dryness.