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US 2009/0264618 A1Published application
Compounds With a Branched Linker
OwnerHerbert Andres, Hans-Peter Josel +3inventors
InventorsHerbert Andres, Hans-Peter Josel, Eva Hoess, Rupert Herrmann, Herbert Von Der Eltz
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Abstract
Disclosed herein are branched linkers of the formula: Zn-Y-Xm Wherein X, Y, Z, m, and n are as defined herein. The branched linkers are useful for producing conjugates that are used in diagnostic or therapeutic methods. Methods of producing the branched linkers are also described.
Claims22
A method for preparing conjugates of the general formula (I):
- Zn-Y-Xm (I)
- in which Z denotes at least one reactive functional group or a binding group and X is a reactive functional group which is bound covalently to Z via a linker Y wherein the linker is a branched linker which has a molecular weight of >1000 Da and contains at least one charge carrier, n is an integer from 1 to 10 and m is 1 or 2, for the production of conjugates.
A method for preparing conjugates of the general formula (I):
- Zn-Y-Xm (I)
- in which Z denotes at least one reactive functional group or a binding group and X is a reactive functional group which is bound covalently to Z via a linker Y wherein the linker is a branched linker which has a molecular weight of >1000 Da and contains at least one charge carrier and at least one hydrophilic group, n is an integer from 1 to 10 and m is 1 or 2, for the production of conjugates.
22-30. (canceled)
Dependencies are inferred from the claim text.