Beta adrenergic receptor agonists for treatment of pain and/or inflammation
AssigneeWarsaw Orthopedic, Inc., An Indiana Corporation
InventorsJohn Myers ZANELLA, Sara D. Waynick
Life of this patent
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Abstract
Effective treatments of pain and/or inflammation are provided. Through the administration of an effective amount of at least one beta adrenergic agonist at or near a target site, one can reduce, prevent or treat pain and/or inflammation.
Claims20
An implantable drug depot useful for reducing, preventing or treating pain and/or inflammation in a patient in need of such treatment, the implantable drug depot comprising a therapeutically effective amount of a beta-2 adrenergic agonist, the depot being implantable at a site beneath the skin to reduce, prevent or treat pain and/or inflammation, wherein the drug depot is capable of releasing an effective amount of the beta-2 adrenergic agonist over a period of at least one day.
A method of treating or preventing pain and/or inflammation in a patient in need of such treatment, the method comprising administering one or more biodegradable drug depots comprising a therapeutically effective amount of a beta-2 adrenergic agonist to a target tissue site beneath the skin, wherein the drug depot releases an effective amount of the beta-2 adrenergic agonist over a period of at least 1 day.
A method of reducing pain and/or inflammation in a patient in need of such treatment, the method comprising delivering one or more biodegradable drug depots comprising a therapeutically effective amount of a beta-2 adrenergic agonist to a target tissue site beneath the skin of the patient, wherein the drug depot releases an effective amount of the beta-2 adrenergic agonist over a period of at least 1 day.
An implantable drug depot useful for reducing, preventing or treating pain and/or inflammation in a patient, the implantable drug depot comprising a therapeutically effective amount of beta adrenergic agonist and a polymer;
- wherein the drug depot is implantable at a site beneath the skin to reduce, prevent or treat pain and/or inflammation, and the depot is capable of releasing (i) about 5% to about 20% of the beta adrenergic agonist relative to a total amount of the beta adrenergic agonist loaded in the drug depot over a first period of up to 72 hours and (ii) about 21% to about 99% of the beta adrenergic agonist relative to a total amount of the beta adrenergic agonist loaded in the drug depot over a subsequent period of up to 6 months.
Dependencies are inferred from the claim text.