Novel Crystalline Forms of Antidiabetic Compounds
OwnerZhiguo Jake Song, Arlene E McKeowninventors
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Abstract
A novel crystalline anhydrate of the free acid and a crystalline anhydrous besylate salt of a selective PPAR gamma partial agonist which has a fused bicyclic aromatic group attached to an oxypropanoic acid moiety are stable and non-hygroscopic. The compounds are suitable for preparing pharmaceutical formulations for the treatment of type 2 diabetes, hyperglycemia, obesity, and dyslipidemia.
Claims24
The compound (2S)-2-({6-chloro-3-[6-(4-chlorophenoxy)-2-propylpyridin-3-yl]-1,2-benzisoxazol-5-yl}oxy)propanoic acid having formula I:
- characterized as being a crystalline anhydrous free acid or a crystalline anhydrous benzenesulfonate salt.
The benzenesulfonic acid salt of (2S)-2-({6-chloro-3-[6-(4-chlorophenoxy)-2-propylpyridin-3-yl]-1,2-benzisoxazol-5-yl}oxy)propanoic acid having formula Ia:
Dependencies are inferred from the claim text.