Therapeutic Reprogramming, Hybrid Stem Cells and Maturation
AssigneePrimeGen Biotech LLC
InventorsChauncey B. Sayre, Francisco J. Silva
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Abstract
Therapeutically programmed cells and methods for making such cells are provided. Therapeutically programmed cells are stem cells which have been matured such that they represent either a more differentiated state or a less differentiated state after contact with stimulatory factors. The therapeutically reprogrammed cells are suitable for cellular regenerative therapy and have the potential to differentiate into more committed cell lineages. Additionally, hybrid stem cells suitable for therapeutic reprogramming and cellular regenerative therapy are provided.
Claims23
A therapeutic reprogramming method comprising:
- isolating a stem cell;
- contacting said stem cell with a medium comprising stimulatory factors which induce development of said stem cell into a therapeutically reprogrammed cell;
- recovering said therapeutically reprogrammed cell from said medium;
- and
- implanting said therapeutically reprogrammed cell, or a cell matured therefrom, into a host in need of a therapeutically reprogrammed cell.
A therapeutically reprogrammed cell comprising:
- an SSC which has been exposed to stimulatory factors which have caused said SSC to mature or differentiate into a totipotent or a pluripotent cell.
A therapeutically reprogrammed cell comprising:
- a pluripotent stem cell which has been exposed to stimulatory factors which have caused said pluripotent stem cell to mature or differentiate into a more committed cell lineage.
Dependencies are inferred from the claim text.