Raman Analysis
AssigneeThe Science and Technology Facilities Council
InventorsPavel Matousek, Anthony William Parker
Life of this patent
Estimating the term…
Abstract
Properties of turbid or scattering samples are determined using Raman spectroscopy with probe light delivered to and subsequently collected from the sample using a transmission geometry. The technique may be applied to pharmaceutical products such as tablets, diagnostic tests such as lateral flow diagnostic strips, and elsewhere.
Claims27
1-42. (canceled)
A method of determining one or more properties of a pharmaceutical dosage formulation, such as a tablet, capsule or gel capsule, comprising:
- exposing a first surface of said formulation to incident radiation;
- receiving, from a second surface of said formulation spaced from said first surface, elements of said incident radiation forward scattered through said formulation from said first surface to said second surface;
- detecting Raman scattered spectral elements in said received radiation;
- and
- determining one or more of said properties from said detected Raman scattered elements.
A method of analysing the bulk of a pharmaceutical dosage formulation comprising directing incident radiation at said dosage formulation and detecting Raman radiation scattered in the dosage formulation using a transmission geometry.
Apparatus for analysing a pharmaceutical dosage formulation, comprising:
- a carrier for retaining a dosage formulation;
- illumination optics arranged to direct incident radiation to a first surface of a said formulation;
- reception optics arranged to receive, from a second surface of said formulation spaced from said first surface, elements of said incident radiation forward scattered from said first surface through said formulation to said second surface, and to detect Raman scattered spectral elements in said received radiation.
Dependencies are inferred from the claim text.