2' Deoxy-2'-Alkylnucleotide Containing Nucleic Acid
AssigneeSirna Therapeutics, Inc.
InventorsNassim Usman, Alexander Karpeisky, Leonid Beigelman, Anil Modak
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Abstract
2′-deoxy-2′-alkylnucleotides useful for stabilizing enzymatic nucleic acid molecules and antisense molecules.
Claims4
A 2′-deoxy-2′-C-allyl nucleoside selected from the group consisting of 2′-deoxy-2′-C-allyl-beta-D-ribofuranosyl uridine, 2′-deoxy-2′-C-allyl-beta-D-ribofuranosyl cytidine, 2′-deoxy-2′-C-allyl-beta-D-ribofuranosyl adenosine, and 2′-deoxy-2′-C-allyl-beta-D-ribofuranosyl guanosine.
An oligonucleotide A RNA comprising one or more 2′-C-allyl nucleotide 2′-deoxy-2′-C-allyl nucleotides selected from the group consisting of 2′-deoxy-2′-C-allyl-beta-D-ribofuranosyl uridine, 2′-deoxy-2′-C-allyl-beta-D-ribofuranosyl cytidine, 2′-deoxy-2′-C-allyl-beta-D-ribofuranosyl adenosine, and 2′-deoxy-2′-C-allyl-beta-D-ribofuranosyl guanosine.
The oligonucleotide RNA of claim 3, wherein said oligonucleotide RNA is single stranded.
Dependencies are inferred from the claim text.