Metadherin polypeptides, encoding nucleic acids and methods of use
AssigneeThe Burnham Institute
InventorsErkki Ruoslahti, Darren M. Brown
Life of this patent
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Abstract
Metadherin, a protein that controls metastasis, and variants of metadherin are described. DNA sequences encoding the same and methods of production are described. Therapies involving the application of metadherin, binding agents that bind to metadherin, such as antibodies, and expression modulating agents, such as siRNA, are described. The use of metadherin or metadherin variants for delivering desired substances to particular lung tissue is described. A method of diagnosing metastatic cells based on the presence of metadherin is described.
Claims18
1-24. (canceled)
A method of delivering an agent to the lung vasculature of a patient, comprising:
- linking an agent to a metadherin protein to create a metadherin targeted agent;
- and
- administering said metadherin targeted agent to a patient, thereby delivering an agent to a lung vasculature of the patient.
29-44. (canceled)
A method of delivering an agent to the lung vasculature of a patient, said method comprising administering an agent linked to a metadherin protein to a patient, thereby delivering an agent to a lung vasculature of the patient.
Dependencies are inferred from the claim text.