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OwnerSanjay Pandey, Robert McKay +2inventors
InventorsSanjay Pandey, Robert McKay, Sanjay Bhanot, Xing-Xian Yu
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Disclosed herein are compounds, compositions and methods for modulating the expression of LMW-PTPase in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Also provided are methods for the prevention, amelioration and/or treatment of diabetes, insulin resistance, insulin deficiency, hypercholesterolemia, hyperglycemia, dyslipidemia, hyperlipidemia, hypertriglyceridemia, and hyperfattyacidemia. In some embodiments, the diabetes is type II diabetes by administration of antisense compounds targeted to LMW-PTPase.
A chimeric antisense compound of 15 to 35 nucleobases comprising at least two chemical modifications and targeted to at least a 12 nucleobase portion of an active target segment of SEQ ID NO:
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The method of claim 42 wherein the triglyceride levels are blood, plasma, or serum triglyceride levels.
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The method of claim 42 wherein cholesterol is LDL cholesterol, VLDL cholesterol or any combination thereof.
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Dependencies are inferred from the claim text.