Inhibitors of akt (protein kinase b)
AssigneeEli Lilly and Company
InventorsSajan Joseph, Renhua Li, Michael Ray Myers, Aktham Aburub, Jenny Pingqi Dai, Christopher Randall Schmid
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Abstract
4-[5-(2-Amino-ethanesulfonyl)-isoquinolin-7-yl]-phenol or a pharmaceutically acceptable salt thereof or a hydrate of the compound or the salt thereof as Akt inhibitors that are antineoplastic and/or antiviral agents as well as compositions comprising these compounds and methods of using these compounds.
Claims17
A compound which is 4-[5-(2-Amino-ethanesulfonyl)-isoquinolin-7-yl]-phenol or a pharmaceutically acceptable salt thereof, a hydrate of the compound, a hydrate of a pharmaceutically acceptable salt of the compound.
4-8. (canceled)
4-[5-(2-Amino-ethanesulfonyl)-isoquinolin-7-yl]-phenol monohydrochloride hemihydrate in crystalline form having an X-ray powder diffraction pattern with intense peaks at 20=4.9, 14.8, and 10.2.
Dependencies are inferred from the claim text.