Loading patent…
AssigneeWayne State University
InventorsRoy Sundick, Paul Christopher Roberts, Yufang Yang, Andrew Scott Herbert
Estimating the term…
The present invention provides novel virus vaccines with augmented, e.g., enhanced and/or extended immunogenicity. The virus vaccines of the invention comprise an envelope-bound immunomodulatory protein, e.g., a cytokine, chemokine or costimulatory molecule. The immunomodulatory protein serves as an adjuvant to augment, e.g., enhance or extend the immunogenicity of the virus vaccine, thereby augmenting, e.g., enhancing or extending immune response to the virus when administered to a subject.
A composition comprising an enveloped virus expressing an envelope-bound, immunomodulatory protein linked to a viral envelope protein, or to a fragment thereof.
A method for producing an enveloped virus expressing an envelope-bound, immunomodulatory protein, the method comprising a) transforming a host cell with an expression vector encoding an immunomodulatory protein and a viral envelope protein, or a fragment thereof, and b) infecting the cell with an enveloped virus, thereby producing an enveloped virus expressing an envelope-bound, immunomodulatory protein.
A method for inducing an immune response in a animal which comprises administering to the animal an effective amount of a composition comprising an inactive virus expressing an envelope-bound immunomodulatory protein, wherein the immune response induced by the animal is more robust as compared to the immune response that could have been induced in an animal by the virus without the envelope-bound immunomodulatory protein.
A method for treating or preventing a viral infection in a animal comprising administering to the animal an inactive, enveloped virus expressing an envelope-bound immunomodulatory protein.
A pharmaceutical composition comprising an enveloped virus expressing an envelope-bound immunomodulatory protein linked to a viral envelope protein and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.