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US 2009/0214586 A1Published application
Combination Vaccines With Whole Cell Pertussis Antigen
AssigneeNovartis AG
InventorsMario Contorni, Donatella Mannucci
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Abstract
Vaccines have been studied that comprise (a) D-T-Pw-HepB-Hib antigens and (b) one or more meningococcal conjugate antigens. A number of improvements and variations of these vaccines have been discovered. The vaccines can be prepared extemporaneously at the time of use by mixing together two components: (a) a first component comprising D, T, wP and HBsAg antigens; and (b) a second component comprising a Hib conjugate and one or more meningococcal conjugates.
Claims38
A vaccine composition comprising:
- (i) a diphtheria toxoid, ‘D’;
- (ii) a tetanus toxoid, ‘T’;
- (iii) a cellular pertussis antigen, ‘wP’;
- (iv) a hepatitis B virus surface antigen, ‘HBsAg’;
- (v) a Haemophilus influenzae type b (‘Hib’) capsular saccharide conjugated to a carrier protein;
- and
- (vi) at least one Neisseria meningitidis capsular saccharide conjugated to a carrier protein, wherein the H. influenzae type b capsular saccharide and the N. meningitidis capsular saccharide(s) are each conjugated to a tetanus toxoid carrier protein.
4 more elements
Dependencies are inferred from the claim text.