Progenitor Cells and Uses Thereof
OwnerRobert A. Weinberg, Sendurai A. Mani +1inventors
InventorsRobert A. Weinberg, Sendurai A. Mani, Mai-Jing Liao
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Abstract
Methods for preparing progenitor cells are described where epithelial cells are induced to undergo epithelial-mesenchymal transition as a result of exposure to an inducing agent or introduction of a gene therein that induces epithelial-mesenchymal transition. Progenitor cells resulting therefrom have use in cell-based therapies, among other utilities.
Claims46
A method for preparing isolated progenitor cells from epithelial cells comprising the steps of
- a. obtaining a population of epithelial cells;
- b. inducing epithelial-mesenchymal transition (EMT) in the population of epithelial cells, whereby progenitor cells are generated in the population;
- and
- c. isolating progenitor cells from the population after inducing EMT.
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13-15. (canceled)
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28-31. (canceled)
Modified epithelial cells comprising an inducible gene encoding a protein that induces epithelial-mesenchymal transition when the cells are exposed to an inducer.
34-35. (canceled)
Modified progenitor cells comprising a vector comprising a gene encoding a protein that induces epithelial-mesenchymal transition.
39-43. (canceled)
Modified progenitor cells comprising an inducible gene encoding a protein that induces epithelial-mesenchymal transition.
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A method for administering cell therapy to a mammalian subject comprising transplanting into the subject progenitor cells prepared by the method of
- a. obtaining a population of epithelial cells,
- b. inducing epithelial-mesenchymal transition in the population of epithelial cells, whereby progenitor cells are generated in the population, and
- c. transplanting the progenitor cells into the subject.
56-76. (canceled)
A method for identifying a progenitor cell in a cellular population comprising the step of detecting the expression of FOXC2 in the progenitor cell.
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Dependencies are inferred from the claim text.