Peroxisome proliferator-activator receptor delta (ppardelta) and the development of preimplantation embryos

Abstract

Methods and compositions for enhancing development of a preimplantation mammalian embryo and for increasing the live birth potential of an in vitro fertilized mammalian embryo are disclosed. An in vitro method of activating the peroxisome proliferator activated receptor δ (PPARδ) in a preimplantation mammalian embryo comprises culturing an embryo in an embryo culture medium, and upon or after commencement of expression of PPARδ in the cells of the embryo, activating the PPARδ by adding an amount of a PPARδ ligand to said medium effective to bind to PPARδ to deter apoptosis in the cells of the cultured embryo and/or increase proliferation of the cells of the cultured embryo.

Dependencies are inferred from the claim text.