Use of oligomers and polymers for drug solubilization, stabilization, and delivery
AssigneeSoane Family Trust
InventorsDavid S. Soane, Daniel J. Suich
Life of this patent
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Abstract
The invention relates to the use of oilgomers and polymers capable of rendering insoluble drugs soluble, protecting unstable drugs, and facilitating the delivery of drugs to their site of action. This invention further relates to processes for the preparation of such oilgomers and polymers, and to compositions containing them.
Claims35
A surfactant comprising a hydrophobic element having a log P value greater than 0 covalently attached to a hydrophilic element, wherein said hydrophobic element has a molecular weight of between about 10-2000 daltons, and wherein said surfactant is capable of forming a micelle that encapsulates a hydrophobic drug, said micelle having a core comprising said hydrophobic drug, wherein said core is substantially free of said hydrophobic element.
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A surfactant comprising a first hydrophilic element covalently attached to a first end of a hydrophobic element and a second hydrophilic element covalently attached to a second end of said hydrophobic element, wherein said first and second hydrophilic elements are different in size and/or shape, and wherein said surfactant is capable of forming a micelle that has a core comprising a hydrophilic drug.
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An oligomer, polymer, and/or mixtures thereof for the protection of a protein drug comprising at least one recognition element covalently attached to a hydrophilic element, wherein said recognition element or elements interact noncovalently with said protein drug to form a complex in which said protein drug is protected from degradation, recognition by the immune system, and/or renal excretion.
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Dependencies are inferred from the claim text.