Selective androgen receptor modulators, analogs and derivatives thereof and uses thereof

A compound represented by the structure of formula I:

• wherein
• X is C or N;
• W is C or N;
• X1 is N, NH, N(C1-4alkyl), NAc, NCOOH, or a bond;
• or X1 and X3 together with X2 and X5 to which X1 and X3 are attached, form a saturated or unsaturated, substituted or unsubstituted 5- or 6-membered ring;
• or X1 and X5 together with X2 to which X1 and X5 are attached form a saturated or unsaturated, substituted or unsubstituted 5- or 6-membered ring and A is nothing;
• P is H or formula II:
• X2 is C1-4alkylne, SO2, C(O), CH—[CH2—C4-8ring)], CH(C1-4 alkyl), CH(NH2), CH(OH), CH(C1-4haloalkyl), a bond;
• or X2 and R3 together with X1, to which X2 is attached, form a ring, which is a saturated or unsaturated, substituted or unsubstituted 5 or 6 membered ring;
• or X2 and X5 form a saturated or unsaturated, substituted or unsubstituted 5- or 6-membered ring and A is nothing,
• X3 is Cl1-4alkylene, NH, N, CH(OH), a bond, or X3 and X1 together with X2 and X5 to which X1 and X3 are attached form a saturated or unsaturated, substituted or unsubstituted 5- or 6-membered ring;
• or X3 and X5 form a saturated or unsaturated, substituted or unsubstituted 5- or 6-membered ring and A is nothing;
• or X3 and X4 form together a double bond or form together a saturated or unsaturated, substituted or unsubstituted 3 to 6 membered ring.
• X4 is O, S, SO, C(O), S(O)[═CHCH2N(CH3)]3 SO2, NH, NHR′, NO, C1-4alkylene, C(OH)[CH2CH2N(CH3)2], C[═CHCH2N(CH3)2], PO(C1-4alkyl), N[CH2CH2N(CH3)2], NO[CH2CH2N(CH3)2] or a bond;
• or X4 and X5 together with X3, to which X4 and X5 are attached form a saturated or unsaturated membered, substituted or unsubstituted 5- or 6-membered ring and A is nothing;
• or X3 and X4 form together a double bond or form together a saturated or unsaturated, substituted or unsubstituted 3 to 6 membered ring.
• X5 is a carbon or X5 and X1 together with X2 to which X1 and X5 are attached form a saturated or unsaturated, substituted or unsubstituted 5- or 6-membered ring and A is nothing;
• or X3 and X2 form a saturated or unsaturated, substituted or unsubstituted 5- or 6-membered ring and A is nothing;
• or X5 and 3 form a saturated or unsaturated, substituted or unsubstituted 5- or 6-membered ring and A is nothing;
• or X5 and X4 together with X3, to which X5 and X4 are attached form a saturated or unsaturated, substituted or unsubstituted 5- or 6-membered ring and A is nothing,
• A is nothing, H, OH, SH, NH2, C1-4alkyl, CHF2, CH2F, CF3, CN, CH2OH, CH2O(C1-4alkyl), CH2O(C1-4acyl), CH2CN, CH2N3, CH2NCS, CHO, C(O)O(C1-4alkyl), CONHR′, C(O)N(R′)2, C(O)O(C1-4 alkyl), C(O)R′, CH2CF3, CF2CF3, CH2OR′CH2C(O)CH7═CH2 or C(O)CH═CH2;
• or A with R forms a double bond represented by formula III:
• Z is H, CN, NO2, NHC(O)CH3, C1-4alkyl, F, Cl, I or Br;
• Y is H, C1-4alkyl, CF3, NO2, CN, F, Cl, I or Br;
• Q is H, CN, OH, NO2, halide, CF, C2-6alkenyl, C2-6-alkynyl, C(O)CH2NH2, C(O)NH(C1-4alkyl), C(O)N(C1-4alkyl), C(O)NH2, NH(C1-4alkyl), NHC(O)NH(C1-4alkyl), CH2C(O)NH2, NHC(O)NH2, NHCO(C1-4alkyl), NHSO2(C1-4alkyl), O—[CH2CH2CH(CH3)2], O—[CH2CH2(C1-4-cycloalkyl)], O—[CH2CH2(C4-8heterocycloalkyl)] or O—[CH2CH2N(CH3)2];
• R is H, OH, C1-4alkyl, CF3, CH2OH, O(C1-4alkyl) or O(C1-4acyl);
• R1 is H, OH, NH2, F, Cl, Br or I;
• R2 is H, benzyl substituted with R6, (CH2)2—O-p-cyanophenyl, CH2—O-p-cyanophenyl, or CH═CH—O-p-cyanophenyl;
• R3 is H, C1-4alkyl, halide, CN, NO2;
• or R3 and X2 together with the benzene ring to which R3 is attached and X1 to which X2 is attached form a ring, which is a saturated or unsaturated, substituted or unsubstituted 5- or 6-membered ring;
• R′ is NH2, OH or CH3;
• R4 and R5 are independently H, CH3, halide, OH, C1-4alkyl, C1-6cycloalkyl, halo(C1-4alkyl), phenyl, aryl, C4-8heterocycloalkyl, or hydroxy(C1-4alkyl);
• R6 is CN, NO2, NHC(O)CH3 or halide;
• wherein
• if P is formula II, X is C, X1 is NH, X2 is C(O), X3 is CH2, R is OH and A is alkyl or haloalkyl, then X4 is S(O)[═CHCH2N(CH3)2], C(OH)[CH2CH2N(CH3)2], C[═CHCH2N(CH3)2], N[CH2CH2N(CH3)2], P(O)(C1-4alkyl) or N(O)[CH2CH2N(CH3)2];
• or
• if P is formula II, X is C, X1 is NH, X2 is C(O), X3 is CH2, R is OH or OAlk and X4 is O, S, NH, S, SO, SO2 or alkylene, then A is CN, CH2OH, CH2O(C1-4alkyl), CH2O(C1-4acyl), CH2CN, CH2N3, C1-2NCS, CHO, C(O)O(C1-4alkyl), CONHR′, C(O)N(R′)2, C(O)O(C1-4 alkyl), C(O)R′, CH2OR′CH2C(O)CH═CH2 or C(O)CH—CH2;
• or
• if P is phenyl, X is C, X1 is NH, X2 is C(O), R is OH and A is COOH, X3 is a bond, X4 is CH2, R1, R2 are H then Q is not H,
• or
• if P is formula II, X is C, X3 is CH2, X4 is O, or NH, R1, R2 and R3 are H, and X5 and X1 forms a 5 membered ring, an oxazolidine-2-one then Q is not halogen, or H;
• or
• if P is H, X is C, X1 is NH, X2 is C(O), R is OH, A is alkyl, X3 is a bond or CH2 and X4 is bond or CH2, R1 and R2 are H, then Q is not H or halogen.