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US 2009/0155350 A1Published application
Chlamydia antigens and protein vaccine
AssigneeAventis Pasteur Limited
InventorsANDREW D. MURDIN, RAYMOND P. OOMEN, JOE WANG, PAMELA DUNN
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Abstract
The present invention provides vaccines for immunizing a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae. The vaccine and method employ a full-length, 5′-truncated or 3′-truncated 76 kDa protein of a strain of Chlamydia pneumoniae. Modifications are possible within the scope of this invention.
Claims21
A vaccine composition comprising a substantially purified protein and an adjuvant, wherein the protein comprises
- (a) the amino acid sequence set forth in SEQ ID NO:2, or
- (b) the amino acid sequence set forth in SEQ ID NO:4, or
- (c) an amino acid sequence comprising an immunogenic fragment of SEQ ID NO:2, the fragment consisting of at least amino acids 1-452 of SEQ ID NO:2, or
- (d) an amino acid sequence comprising an immunogenic fragment of SEQ ID NO:2, the fragment consisting of at least amino acids 69-651 of SEQ ID NO:2;
- wherein the adjuvant facilitates delivery and/or enhances an immune response to the part of the protein having the amino acid sequence defined in (a) to (d).
2 more elements
Dependencies are inferred from the claim text.