Process to form nano-sized materials, the compositions and uses thereof
OwnerHoward W. H. Leeinventor
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Abstract
Various embodiments of the invention include systems and methods of generating nano-sized salt particles. These methods include generation of a supersaturated solution of a salt MX by mixing of salts MY and NX in which the solubility of MX is lower than that of MY, NX or NY. In some embodiments, nano-sized particles of MX are grown further by further adiabatic addition of salts MY and/or NX. In some embodiments, MX includes potassium nitrate. Some embodiments include compositions of MX configured for use in treatment of dentine sensitivity.
Claims23
A method for the production of nano-sized particles of a salt MX, the method comprising:
- mixing reactant salts MY and NX in a solvent S1, in the presence of a soft template, chosen such that the solubilities of salts MY, NX and NY in S1 are larger than the solubility of salt MX in S1 at a reaction temperature;
- forming the nano-sized particles of salt MX by nucleation under supersaturated conditions;
- and
- separating the nano-sized particles of salt MX from the solvent.
A method for the size controlled production of nano-sized salt particles, the method comprising:
- a) adding a salt MY to a solvent comprising NX and a coordinating species, under non-adiabatic conditions;
- b) mixing the resulting solution to generate a supersaturated solution of salt MX and NY,
- c) maintaining said solution under non-adiabatic conditions to promote the nucleation of seed nano-sized particles of MX;
- d) increasing the size of the seed nano-sized particles of MX to a specific size range by further controlled addition of MY and NX under adiabatic conditions;
- and
- e) stopping the addition of MY or NX so as to stop the growth of the formed nanoparticles of MX;
- and
- f) separating the nano-sized particles of MX having a specific size range from N ions or Y ions, wherein M is a first organic or inorganic cation, Y is a first anion, N is a second different organic or inorganic cation, and X is a second different anion.
A method of treating dentin sensitivity, which method comprises:
- applying to the dentin nano-sized particles in a therapeutically effective amount in a pharmaceutically acceptable carrier;
- and
- allowing the nano-sized particles to penetrate tubules of the dentine.
A composition for the production of nano-sized particles, which composition comprises:
- a supersaturated solution of a salt MX, M including an organic or inorganic cation non-adiabatically introduced to the solution as a salt MY, X including an organic or inorganic anion non-adiabatically introduced to the solution as a salt NX, the supersaturated solution being at a temperature of less than about 45° C.;
- and
- a soft template configured for controlling the formation of nano-sized particles of the salt MX.
A composition comprising:
- nano-sized particle of a salt MX configured to penetrate dentine tubules;
- and
- a pharmaceutical carrier suitable for introduction of the salt MX into a patient.
The method of claim 210 wherein the nano-sized particles are in a size between 10−9 and 10−7 meters.
Dependencies are inferred from the claim text.