US 2009/0024224 A1 · Implantation of cartilage

Abstract

The invention is directed towards a process for implanting a cartilage graft into a cartilage defect and sealing the implanted cartilage graft with recipient tissue by creating a first bore down to the bone portion of the cartilage defect, creating a second shaped bore that is concentric to and on top of the first bore to match the shape and size of the cartilage graft, treating the first bore and the second shaped bore at the defect site with a bonding agent, treating the circumferential area of the cartilage graft with a bonding agent, inserting the cartilage graft into the defect site and wherein the superficial surface of the cartilage graft is at the same height as the surrounding cartilage surface. The first and second bonding agents may be activated by applying a stimulation agent to induce sealing, integration, and restoration of the hydrodynamic environments of the recipient tissue. The invention is also directed towards a process for repairing a cartilage defect and implanting a cartilage graft into a human or animal by crafting a cartilage matrix into individual grafts, cleaning and disinfecting the cartilage graft, applying a pretreatment solution to the cartilage graft, removing cellular debris using an extracting solution to produce a devitalized cartilage graft, implanting the cartilage graft into the cartilage defect with or without an insertion device, and sealing the implanted cartilage graft with recipient tissue. The devitalized cartilage graft is optionally recellularized in vitro, in vivo, or in situ with viable cells to render the tissue vital before or after the implantation. The devitalized cartilage graft is also optionally stored between the removing cellular debris and the recellularizing steps. The invention is further directed toward a repaired cartilage defect.

Claims26

Dependent claims

1-200. (canceled)

A process for implanting a cartilage graft into a cartilage defect and sealing the implanted cartilage graft with the recipient tissue, comprising

a. selecting an osteochondral plug that matches the size, contour, and location of the defect site;
b. creating a first bore down to the bone portion of the cartilage defect;
c. creating a second shaped bore that is concentric to and on top of said first bore to match the shape and size of the cartilage cap of said osteochondral plug;
d. treating said first bore and said second shaped bore at said defect site with a first bonding agent;
e. treating the circumferential area of said cartilage cap on said osteochondral plug with a second bonding agent;
f. inserting said osteochondral plug into said defect site using or not using an insertion device and wherein the superficial surface of said cartilage cap is at the same height as the surrounding cartilage surface;
and
wherein said first and second bonding agents are activated by applying a stimulation agent to induce sealing, integration, and restoring the hydrodynamic environments of the recipient tissue.

5 more elements

A process for implanting a cartilage graft into a cartilage defect and sealing the implanted cartilage with the recipient tissue, comprising

a. selecting an osteochondral plug and cartilage slices that match the size, contour, and location of the defect site;
b. creating a first bore down to the bone portion of the cartilage defect;
c. creating a second shaped bore that is concentric to and on top of said first bore to match the shape and size of the cartilage cap of said osteochondral plug;
d. tailoring the cartilage slices according to the shape and the sizes of said second shaped bore and the contour of the joint surface at said cartilage defect;
e. treating said first bore and said second shaped bore at said defect site with a first bonding agent;
f. treating the circumferential area of said cartilage cap on said osteochondral plug with a second bonding agent;
g. treating the circumferential area of said cartilage slices with said second bonding agent;
h. inserting said osteochondral plug into said defect site using or not using an insertion device and wherein the superficial surface of said cartilage cap is slightly lower than the surrounding cartilage surface;
i. applying a stimulation agent to activate said first and second bonding agents to induce sealing, integration, and restoring the hydrodynamic environments of the recipient tissue;
j. stacking said cartilage slices on top of said osteochondral plug in the defect site until being at the same height as the surrounding cartilage or matching the contour of the surrounding cartilage surface;
wherein said first and second bonding agents are activated by applying a stimulation agent to induce sealing, integration, and restoring the hydrodynamic environments of the recipient tissue;
wherein said cartilage slices are bonded between adjacent slices using said first or second bonding agent;
and
wherein said cartilage slices are bonded with superficial surface of said cartilage cap of said osteochondral plug using said first or second bonding agent before or during implantation.

11 more elements

A process of implanting a cartilage graft into a cartilage defect and sealing the implanted cartilage with recipient tissue, comprising

a. selecting a cartilage disc that matches the size, contour, and location of the defect site;
b. creating a first bore at a cartilage defect site down to a bone portion;
c. creating a second shaped bore that is concentric to and on top of the first bore to match the size and shape of said cartilage disc;
d. treating said first bore and said second shaped bore at said defect site with a first bonding agent;
e. inserting a bone filler into the bone portion of said first bore to provide support towards said cartilage disc;
f. treating the circumferential area of said cartilage disc with a second bonding agent;
p1 g. inserting said cartilage disc into said defect site using or not using an insertion device and wherein the superficial surface of said cartilage disc is at the same height as the surrounding cartilage surface;
and
wherein said first and second bonding agents are activated by applying a stimulation agent to induce sealing, integration, and restoring the hydrodynamic environments of the recipient tissue.

6 more elements

A process for implanting a cartilage graft into a cartilage defect and sealing the implanted cartilage with recipient tissue, comprising

a. selecting a cartilage disc and cartilage slices that match the size, contour, and location of the defect site;
b. creating a first bore at a cartilage defect site down to a bone portion;
c. creating a second shaped bore that is concentric to and on top of the first bore to match the size and shape of said cartilage discs;
d. tailoring the cartilage slices according to the shape and the sizes of said second shaped bore and the contour of the joint surface at said cartilage defect site;
e. treating said first bore and said second shaped bore at said defect site with a first bonding agent;
f. treating the circumferential area of said cartilage disc and cartilage slices with a second bonding agent;
g. inserting a bone filler into the bone portion of said first bore to provide support towards said cartilage disc;
h. inserting said cartilage disc into said defect site using or not using an insertion device and wherein the superficial surface of said cartilage disc is slightly lower than the surrounding cartilage surface;
i. applying an stimulation agent to activate said first and second bonding agents to induce sealing, integration, and restoring the hydrodynamic environments of the tissue;
j. stacking said cartilage slices into the defect site and wherein said stack of cartilage slices is at the same height as or matches the contour of the surrounding cartilage;
wherein said first and second bonding agents are activated by applying a stimulation agent to induce sealing, integration, and restoring the hydrodynamic environments of the recipient tissue;
wherein said cartilage slices are bonded between adjacent slices using said first or second bonding agent;
and
wherein said cartilage slices are bonded with superficial surface of said cartilage disc using said first or second bonding agent before or during implantation.

11 more elements

A process for implanting a cartilage graft into a cartilage defect and sealing the implanted cartilage with the recipient tissue, comprising

a. selecting cartilage slices that match the size, contour, and location of the defect;
b. creating a first bore at a cartilage defect site down to a bone portion;
c. creating a second shaped bore that is concentric to and on top of said first bore to match the size and shape of said cartilage slices;
d. further tailoring the cartilage slices according to the shape and the sizes of said second shaped bore and the contour of the joint surface at said cartilage defect site;
e. treating said first bore and said second shaped bore at said defect site with a first bonding agent;
f. inserting a bone filler into the bone portion of said first blind bore to provide support towards said cartilage slices;
g. treating the circumferential area of said cartilage slices with a second bonding agent;
h. stacking said cartilage slices into said defect and wherein said stack of cartilage slices is at the same height as or matches the contour of the surrounding cartilage;
wherein said first and second bonding agents are activated by applying a stimulation agent to induce sealing, integration, and restoring the hydrodynamic environments of the recipient tissue;
and
wherein said cartilage slices are bonded between adjacent slices before or during implantation using said first or second bonding agent.

8 more elements

A process for implanting a cartilage graft into a cartilage defect and sealing the implanted cartilage with the recipient tissue, comprising

a. selecting cartilage curls or flakes and a cartilage disc that matches the size, contour, and location of the defect site;
b. creating a first bore at a cartilage defect site down to a bone portion;
c. creating a second shaped bore that is concentric to and on top of the first bore to match the size and shape of said cartilage disc;
d. treating said first bore and said second shaped bore at said defect site with a first bonding agent;
e. inserting a bone filler into the bone portion of said first bore to provide support towards said cartilage disc;
f. treating the circumferential area of said cartilage disc with a second bonding agent;
g. inserting said cartilage curls or flakes into said defect site;
h. inserting said cartilage disc on top of the inserted cartilage curls or flakes in said defect site using or not using a insertion device and wherein the superficial surface of said cartilage disc is at the same height as the surrounding cartilage surface;
wherein said first and second bonding agents are activated by applying a stimulation agent to induce sealing, integration, and restoring the hydrodynamic environments of the recipient tissue;
and
wherein said cartilage curls or flakes are mixed with or without a carrier before insertion.

8 more elements

A process for implanting a cartilage graft into a cartilage defect and sealing the implanted cartilage with the recipient tissue, comprising

a. selecting cartilage curls or flakes and one or more cartilage slices that match the size, contour, and location of the defect site;
b. creating a first bore at a cartilage defect site down to a bone portion;
c. creating a second shaped bore that is concentric to and on top of the first bore to match the size and shape of said cartilage slices;
d. treating said first bore and said second shaped bore at said defect site with a first bonding agent;
e. inserting a bone filler into the bone portion of said first bore to provide support towards said cartilage curls or flakes and cartilage slices;
f. treating the circumferential area of said cartilage slices with a second bonding agent;
g. inserting said cartilage curls or flakes into said defect site.
h. stacking said cartilage slices on top of the inserted said cartilage curls or flakes and wherein said stack of cartilage slices is at the same height or matches the contour of the surrounding cartilage;
wherein said first and second bonding agents are activated by applying a stimulation agent to induce sealing, integration, and restoring the hydrodynamic environments of the recipient tissue;
and
wherein said shaved cartilage curls or flakes are mixed with or without a carrier before insertion.

8 more elements

Dependencies are inferred from the claim text.

Implantation of cartilage

Life of this patent

Implantation of cartilage

Life of this patent

Abstract

Claims26