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US 2009/0023859 A1Published application
Polyoxyalkylene derivative
AssigneeNof Corporation
InventorsKenji Sakanoue, Kenichiro Nakamoto, Yuji Yamamoto, Hiroki Yoshioka
Life of this patent
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Abstract
A novel polyoxyalkylene derivative represented by the following formula (1), wherein each symbol is as defined in the specification, which has a functional group capable of reacting with various physiologically active substances according to the object is provided.
Claims17
A polyoxyalkylene derivative represented by the following formula (1)
- wherein
- Z is a peptide residue consisting of 2 to 10 amino acid residues, wherein one or more amino acid residues have a side chain containing a functional group,
- OA is an oxyalkylene group having 2 to 4 carbon atoms,
- R is a hydrogen atom or a hydrocarbon group having 1 to 4 carbon atoms,
- X1 and X2 are groups containing a succinimide group, a maleimide group, an amino group, a carboxyl group, a carbonate group, an aldehyde group, a sulfonyl group, a thiol group, a vinyl group, an allyl group or a hydroxyl group,
- Y and W are each independently a divalent group containing a group selected from the group consisting of
- —CONH—, —NHCO—, —OCONH—, —NHOCO—, —COO—, —OOC—, —COS—, —SOC—, —CH2NH—, —NHCH2—, —S—CH<, >CH—S—, —CH2—S—, —S—CH2—, —S—S— and —O—,
- n is an integer of 5-1000, m is an integer of 5-800, j1 is an integer of 0-12, j2 is an integer of 0-8, k is an integer of 0-11, wherein 1<j1+j2≦12, 2≦k+j1≦12, 3≦k+j1+j2≦12, 30≦(n×k)+(m×j1)≦2000.
5 more elements
Dependencies are inferred from the claim text.