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AssigneeThe Board of Trustees of the University of Illinois
InventorFederico A. Zuckermann
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Exogenous cDNA capable of expressing interferon″ activity, exogenous interferon″ protein, inducers of endogenous interferon″ protein activity, inducers of endogenous interferon $ protein activity, inducers of endogenous interferon′ activity, or inducers of other immune-enhancing activity can be combined with a vaccine to enhance an immune response. Specifically disclosed are adjuvant and vaccine combinations where the adjuvant comprises a cDNA capable of expressing interferon″ activity, a complex comprising polyriboinosinic-polyribocytidilic acid, or a complex comprising polyriboinosinic-polyribocytidilic acid, poly-L-lysine, and carboxymethylcellulose and where the vaccine is a live vaccine virus derived from a virus causing porcine reproductive and respiratory syndrome disease.
An adjuvant composition comprising a nucleic acid capable of expressing an interferon alpha in a pig in an amount sufficient to enhance an immune response to a PRRS virus when administered to the pig.
A method for enhancing an immune response of an animal to a vaccine comprising the steps of:
A composition comprising an effective amount of a PRRS vaccine antigen composition and an effective amount of an adjuvant wherein the adjuvant is a nucleic acid capable of expressing interferon α, wherein the amount of the adjuvant is sufficient to enhance the animal's immune response to the vaccine and wherein the vaccine antigen is present in an amount sufficient to raise an immune response to the antigen.
Dependencies are inferred from the claim text.