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US 2009/0013998 A1Published application
Inhalable tiotropium and container therefor
AssigneeBoehringer Ingelheim International GmbH
InventorsThomas Nilsson, Mattias Myrman, Sven Calander, Alf Niemi
Life of this patent
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Abstract
A medical product suitable for storing and delivering a pre-metered dose of tiotropium, devices containing the same, and methods of using the same.
Claims25
A medical product comprising a dry powder medicament dose loaded into a container for use in a dry powder inhaler, wherein
- the dry powder medicament dose comprises a fine particle dose of tiotropium and at least one dry excipient present in the form of finely divided particles;
- the medical product comprises a moisture-tight seal foil permanently fixed to the container in such a way that the container and the seal foil together form a dry, moisture-tight barrier seal arranged to be opened by a cutter of the dry powder inhaler;
- the dry, moisture-tight barrier seal prevents ingress of moisture into the powder medicament dose to thereby preserve a fine particle dose during the in-use time and shelf life of the medical product;
- and
- the dry powder medicament dose in the container is formed by either volumetric or electric field dose forming methods.
2 more elements
A medical product comprising a dry powder medicament dose loaded into a container for use in a dry powder inhaler, wherein
- the dry powder medicament dose comprises a fine particle dose of tiotropium and at least one additional active pharmaceutical ingredient in the form of finely divided particles;
- the medical product comprises a moisture-tight seal foil permanently fixed to the container in such a way that the container and the seal foil together form a dry, moisture-tight barrier seal arranged to be opened by a cutter of the dry powder inhaler;
- the dry, moisture-tight barrier seal prevents ingress of moisture into the powder medicament dose to thereby preserve a fine particle dose during the in-use time and shelf life of the medical product;
- and
- the dry powder medicament dose in the container is formed by either volumetric or electric field dose forming methods.
2 more elements
A method of treating asthma in an individual, comprising delivering to an individual in need thereof a fine particle dose of tiotropium through a dry powder inhaler, the method comprising the steps of:
- inserting, into the dry powder inhaler, a medical product comprising a dry powder medicament dose loaded into a container adapted for use in a dry powder inhaler, wherein
- the dry powder medicament dose comprises a fine particle dose of tiotropium and at least one dry excipient present in the form of finely divided particles;
- the medical product comprises a moisture-tight seal foil permanently fixed to the container in such a way that the container and the seal foil together form a dry, moisture-tight barrier seal arranged to be opened by a cutter of the dry powder inhaler;
- the dry, moisture-tight barrier seal prevents ingress of moisture into the powder medicament dose to thereby preserve a fine particle dose during the in-use time and shelf life of the medical product;
- and
- the dry powder medicament dose in the container is formed by either volumetric or electric field dose forming methods;
- making the dose available for aerosolizing by cutting open the dry, moisture-tight seal;
- and
- delivering the tiotropium to the individual in an amount sufficient to treat the asthma in the individual.
6 more elements
A method of treating an obstructive pulmonary disease in an individual, comprising delivering to an individual in need thereof a fine particle dose of tiotropium through a dry powder inhaler, the method comprising the steps of
- inserting, into the dry powder inhaler, a medical product comprising a dry powder medicament dose loaded into a container adapted for use in a dry powder inhaler, wherein
- the dry powder medicament dose comprises a fine particle dose of tiotropium and at least one dry excipient present in the form of finely divided particles;
- the medical product comprises a moisture-tight seal foil permanently fixed to the container in such a way that the container and the seal foil together form a dry, moisture-tight barrier seal arranged to be opened by a cutter of the dry powder inhaler;
- the dry, moisture-tight barrier seal prevents ingress of moisture into the powder medicament dose to thereby preserve a fine particle dose during the in-use time and shelf life of the medical product;
- and
- the dry powder medicament dose in the container is formed by either volumetric or electric field dose forming methods;
- making the dose available for aerosolizing by cutting open the dry, moisture-tight seal;
- and
- delivering the tiotropium to the individual in an amount sufficient to treat the obstructive pulmonary disease in the individual.
6 more elements
A method of treating asthma in an individual, comprising delivering to an individual in need thereof a fine particle dose of tiotropium through a dry powder inhaler, the method comprising the steps of:
- inserting, into the dry powder inhaler, a medical product comprising a dry powder medicament dose loaded into a container adapted for use in a dry powder inhaler, wherein
- the dry powder medicament dose comprises a fine particle dose of tiotropium and at least one additional active pharmaceutical ingredient in the form of finely divided particles;
- the medical product comprises a moisture-tight seal foil permanently fixed to the container in such a way that the container and the seal foil together form a dry, moisture-tight barrier seal arranged to be opened by a cutter of the dry powder inhaler;
- the dry, moisture-tight barrier seal prevents ingress of moisture into the powder medicament dose to thereby preserve a fine particle dose during the in-use time and shelf life of the medical product;
- and
- the dry powder medicament dose in the container is formed by either volumetric or electric field dose forming methods;
- making the dose available for aerosolizing by cutting open the dry, moisture-tight seal;
- and
- delivering the tiotropium to the individual in an amount sufficient to treat the asthma in the individual.
6 more elements
A method of treating an obstructive pulmonary disease in an individual, comprising delivering to an individual in need thereof a fine particle dose of tiotropium through a dry powder inhaler, the method comprising the steps of
- inserting, into the dry powder inhaler, a medical product comprising a dry powder medicament dose loaded into a container adapted for use in a dry powder inhaler, wherein
- the dry powder medicament dose comprises a fine particle dose of tiotropium and at least one additional active pharmaceutical ingredient in the form of finely divided particles;
- the medical product comprises a moisture-tight seal foil permanently fixed to the container in such a way that the container and the seal foil together form a dry, moisture-tight barrier seal arranged to be opened by a cutter of the dry powder inhaler;
- the dry, moisture-tight barrier seal prevents ingress of moisture into the powder medicament dose to thereby preserve a fine particle dose during the in-use time and shelf life of the medical product;
- and
- the dry powder medicament dose in the container is formed by either volumetric or electric field dose forming methods;
- making the dose available for aerosolizing by cutting open the dry, moisture-tight seal;
- and
- delivering the tiotropium to the individual in an amount sufficient to treat the obstructive pulmonary disease in the individual.
6 more elements
Dependencies are inferred from the claim text.