Implantable medical devices for local and regional treatment
OwnerPamela Kramer-Browninventor
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Abstract
Implantable medical devices adapted to erodibly release delivery media for local and regional treatment are disclosed.
Claims153
A stent comprising a scaffolding formed from a corrodible metal having one or more recesses in a surface of the scaffolding, the recesses being at least partially filled with a plurality of releasable delivery media comprising an active agent, wherein the active agent is adapted to be released from the delivery media upon release of the delivery media from an implanted stent.
A stent comprising a scaffolding including at least two erodible polymer layers, wherein at least one of the polymer layers comprises a plurality of delivery media comprising an active agent, wherein the active agent is adapted to be released from the delivery media upon erosion of the at least one polymer layer.
A stent comprising a scaffolding including at least two erodible polymer layers, wherein at least one of the polymer layers comprises a plurality of delivery media comprising an active agent, wherein the active agent is adapted to be released from the delivery media upon erosion of the at least one polymer layer, wherein at least one of the polymer layers comprises a filler material that modifies an erosion rate of the scaffolding, wherein the filler has basic degradation products that decrease the erosion rate of the stent scaffolding.
A stent comprising a scaffolding including struts having an abluminal layer, a luminal layer, and a middle layer between the abluminal layer and the luminal layer, each of the layers being formed from erodible polymers, wherein a plurality of delivery media are dispersed within the abluminal layer or luminal layer, wherein an active agent is adapted to be released from the delivery media upon release of the delivery media from the scaffolding of an implanted stent during erosion of the abluminal layer or luminal layer releases the delivery media from the scaffolding.
A stent comprising erodible polymer struts having an abluminal layer, a luminal layer, and a middle layer, wherein a plurality of delivery media comprising an active agent are dispersed within the abluminal layer or luminal layer, wherein the active agent is adapted to be released from the delivery media upon release of the delivery media from the scaffolding, wherein erosion of the abluminal layer or luminal layer releases the delivery media from the scaffolding, wherein at least one of the layers comprises a filler material that modifies an erosion rate of the scaffolding, wherein the filler has basic degradation products that decrease the erosion rate of the stent scaffolding, and wherein the filler is hydroxyapatite.
A method of fabricating a stent comprising:
- co-extruding a tube including at least two erodible polymer layers, wherein at least one of the two erodible polymer layers comprises a plurality of delivery media comprising an active agent;
- and
- cutting a stent pattern in the tube to form a stent scaffolding including at least two erodible polymer layers, wherein the active agent is adapted to be released from the delivery media upon release of the delivery media from the polymer layer of an implanted stent due to erosion of the at least two polymer layers.
A stent comprising a scaffolding having an erodible polymer layer and an erodible metal layer, wherein at least one of the layers comprises a plurality of delivery media comprising an active agent, wherein the active agent is adapted to be released from the delivery media upon release of the delivery media from the scaffolding of an implanted stent due to erosion of one of the scaffolding layers.
A stent comprising a scaffolding having an erodible polymer layer and an erodible metal layer, wherein at least one of the layers comprises a plurality of delivery media comprising an active agent, wherein the active agent is adapted to be released from the delivery media upon release of the delivery media from the scaffolding of an implanted stent due to erosion of one of the layers, and wherein the metal layer is formed from a metal selected from the group consisting of magnesium, manganese, potassium, calcium, sodium, zinc, chromium, iron, cadmium, aluminum, cobalt, vanadium, copper, molybdenum, antimony, and alloys thereof.
A stent comprising a scaffolding including an erodible polymer layer between two erodible metal layers, at least one of the layers comprising a plurality of releasable delivery media comprising an active agent, wherein the active agent is adapted to be released from the delivery media upon release of the delivery media from an implanted stent.
A method of fabricating a stent comprising:
- forming a layered tube comprising an erodible polymer layer within or around an erodible metallic tube, wherein the erodible polymer layer comprises a plurality of delivery media comprising an active agent;
- and
- cutting a stent pattern in the layered tube to form a stent scaffolding, the stent scaffolding having an erodible metallic layer and an erodible polymer layer, wherein the active agent is adapted to be released from the delivery media upon release of the delivery media from the scaffolding of an implanted stent.
A method of fabricating a stent comprising:
- forming a layered tube comprising an erodible polymer layer within or around an erodible metallic tube, wherein the erodible polymer layer comprises a plurality of delivery media comprising an active agent;
- cutting a stent pattern in the layered tube to form a stent scaffolding, the stent scaffolding having an erodible metallic layer and an erodible polymer layer, wherein the active agent is adapted to be released from the delivery media upon release of the delivery media from the scaffolding of an implanted stent;
- forming a cavity in the erodible metallic layer of the scaffolding;
- and
- disposing a plurality of delivery media within the cavity.
A method of forming a stent, comprising:
- forming a gel mixture comprising an erodible polymer, solvent, and a plurality of delivery media, the delivery media comprising an active agent;
- processing the gel mixture to form a tube, the erodible polymer and the delivery media dispersed within the tube;
- and
- forming a stent from the tube.
A method of forming a stent, comprising:
- forming a gel mixture comprising an erodible polymer, solvent, and a plurality of delivery media, the delivery media comprising an active agent;
- processing the gel mixture to form a tube, the erodible polymer and the delivery media dispersed within the tube;
- forming a stent from the tube;
- and
- removing the solvent from the gel mixture during and after forming the tube by cooling the gel mixture with a cooling fluid.
A method of forming a stent, comprising:
- forming a gel mixture comprising an erodible polymer, solvent, and a plurality of delivery media, the delivery media comprising an active agent;
- processing the gel mixture to form a tube, the erodible polymer and the delivery media dispersed within the tube, wherein the processing comprises coextruding the gel mixture around or within a polymer or metallic tube to form the tube, wherein the tube comprises a layer formed from the gel mixture and a layer comprising the polymer or metallic tube;
- and
- forming a stent from the tube.
A method of forming a stent, comprising:
- forming a gel mixture comprising an erodible polymer, solvent, and a plurality of delivery media comprising an active agent;
- fabricating a tube from the gel mixture with a forming apparatus, the tube including a layer comprising the erodible polymer and the delivery media dispersed within the layer;
- and
- forming a stent from the tube.
A method of forming a stent, comprising:
- forming a gel mixture comprising an erodible polymer, solvent, and a plurality of delivery media comprising an active agent, wherein the active agent is adapted to be released from the delivery media upon release of the delivery media from the stent upon implantation;
- fabricating a tube from the gel mixture with a forming apparatus, the tube including a layer comprising the erodible polymer and the delivery media dispersed within the layer;
- and
- forming a stent from the tube.
A stent comprising a structural element having a cavity disposed therein including a plurality of releasable delivery media comprising an active agent, wherein an osmotic pressure gradient between the cavity and the surface of the structural element releases the delivery media from the cavity.
A stent comprising a structural element having a cavity disposed therein including a plurality of releasable delivery media, wherein an osmotic pressure gradient between the cavity and a surface of the structural element releases the delivery media from the cavity, wherein the structural element comprises a coating layer covering the cavity, an opening being through the coating layer, and wherein the coating is erodible.
A stent comprising a structural element having a cavity disposed therein including a plurality of releasable delivery media, wherein an osmotic pressure gradient between the cavity and a surface of the structural element releases the delivery media from the cavity, wherein the osmotic pressure gradient is formed by a difference in concentatrion of an additive in the cavity and at the surface of the structural element, and wherein the additive is a salt.
A stent comprising a structural element having a cavity disposed therein including a plurality of releasable delivery media comprising an active agent, wherein an opening between the cavity and a surface of the structural element, wherein an osmotic pressure gradient between the cavity and the surface of the structural element releases the delivery media through the opening from an implanted stent, and wherein the structural element is formed from an erodible metal.
A stent comprising a structural element having a cavity disposed therein including a plurality of releasable delivery media comprising an active agent, wherein an osmotic pressure gradient between the cavity and a surface of the structural element releases the delivery media through an opening between the cavity and the surface of the structural element, and wherein the structural element is formed from a metal selected from the group consisting of magnesium, manganese, zinc, chromium, iron, aluminum, cobalt, tin, vanadium, copper, and molybdenum.
A stent comprising an erodible scaffolding, the scaffolding comprising a plurality of releasable particles, wherein the particles comprise an active agent and are adapted to be released from the stent upon erosion of the scaffolding.
A stent comprising an erodible scaffolding, the scaffolding comprising a plurality of releasable particles, wherein the particles comprise an active agent and are adapted to be released from the stent upon erosion of the scaffolding, and wherein the active agent is adapted to be released from the particles upon release of the particles from the scaffolding.
A stent comprising an erodible scaffolding, the scaffolding comprising a plurality of releasable particles, wherein the particles comprise an active agent and are adapted to be released from the stent upon erosion of the scaffolding, and wherein the particles are incorporated on or within the scaffolding with an erodible binder, the binder holding the particles together on or within the scaffolding.
A stent comprising an erodible scaffolding, the scaffolding comprising a plurality of releasable particles, wherein the particles comprise an active agent and are adapted to be released from the stent upon erosion of the scaffolding, and wherein the particles are dispersed within an erodible binder disposed above the surface of the scaffolding.
A stent comprising an erodible scaffolding, the scaffolding comprising a plurality of releasable particles, wherein the particles comprise an active agent and are adapted to be released from the stent upon erosion of the scaffolding, and wherein the active agent is encapsulated within, coated on, or dispersed within the particles.
A method of treating a patient vasculature, comprising:
- deploying a stent at an implant site of a vasculature, the stent comprising a scaffolding formed from erodible material, the scaffolding comprising a plurality of releasable delivery media comprising an active agent;
- and
- allowing the delivery media to release from the scaffolding and be transported to a target region of the vasculature.
A method of treating a patient vasculature, comprising:
- deploying a stent at an implant site of a vasculature, the stent comprising a scaffolding formed from erodible material, the scaffolding comprising a plurality of releasable delivery media comprising an active agent, wherein the delivery media are incorporated on or within the scaffolding with an erodible binder, the binder holding the particles together on or within the scaffolding, and wherein the binder comprises a biodegradable polymer or a water soluble polymer;
- and
- allowing the delivery media to release from the scaffolding and be transported to a target region of the vasculature.
A method of treating a patient vasculature, comprising:
- deploying a stent at an implant site of a vasculature, the stent comprising a scaffolding formed from an erodible material, the scaffolding comprising a plurality of releasable delivery media comprising an active agent, and wherein a surface of the delivery media is adapted to bind to the target region of the vasculature;
- and
- allowing the delivery media to release from the scaffolding and be transported to a target region of the vasculature.
A method of treating a patient vasculature, comprising:
- deploying a stent at an implant site of a vasculature, the stent comprising a scaffolding formed from erodible material, the scaffolding comprising a plurality of releasable delivery media comprising an active agent, and wherein a surface of the delivery media comprises a substance incorporated into the surface for selectively binding the surface to a portion of the vasculature, the substance selected from the group consisting of a peptide, an antibody, a small-molecular ligand, and a specific receptor having an affinity to receptors found on endothelial cells;
- and
- allowing the delivery media to release from the scaffolding and be transported to a target region of the vasculature.
A method of treating a patient vasculature, comprising:
- deploying a stent at an implant site of a vasculature, the stent comprising a scaffolding formed from erodible material, the scaffolding comprising a plurality of releasable delivery media comprising an active agent, and wherein the delivery media are incorporated on or within the scaffolding with an erodible binder, the binder holding the particles together on or within the scaffolding;
- and
- allowing the delivery media to release from the scaffolding and be transported to a target region of the vasculature.
A stent comprising:
- a scaffolding formed from an erodible material;
- and
- a delivery coating disposed over at least a portion of the scaffolding, the delivery coating comprising a releasable delivery media dispersed within an erodible binder material, wherein the binder material is adapted to erode and release the delivery media upon implantation of the stent.
A stent comprising:
- a scaffolding formed from an erodible material;
- a delivery coating disposed over at least a portion of the scaffolding, the delivery coating comprising a releasable delivery media dispersed within an erodible binder material, wherein the binder material is adapted to erode and release the delivery media upon implantation of the stent, and wherein the delivery coating is selectively disposed over an abluminal surface or a luminal surface of the scaffolding.
A stent comprising:
- a scaffolding formed from an erodible material;
- a delivery coating disposed over at least a portion of the scaffolding, the delivery coating comprising a releasable delivery media dispersed within an erodible binder material, wherein the binder material is adapted to erode and release the delivery media upon implantation of the stent, and wherein the delivery media comprises an active agent, the delivery media allowing for sustained-release of the active agent into a body of a patient upon release of the delivery media from the binder material.
A method of fabricating a coated stent comprising:
- applying a coating material to a stent scaffolding, the coating material comprising an erodible polymer dissolved in a solvent and a plurality of delivery media dispersed in the solvent;
- and
- removing all or substantially all of the solvent to form a delivery coating over the scaffolding, the delivery coating comprising the plurality of delivery media dispersed in the erodible polymer, wherein the erodible polymer is adapted to erode and release the delivery media upon implantation of the stent.
A method of fabricating a coated stent comprising:
- applying a coating material to a stent scaffolding, the coating material comprising an erodible polymer dissolved in a solvent and a plurality of delivery media dispersed in the solvent;
- removing all or substantially all of the solvent to form a delivery coating over the scaffolding, the delivery coating comprising the plurality of delivery media dispersed in the erodible polymer, wherein the erodible polymer is adapted to erode and release the delivery media upon implantation of the stent;
- and
- forming an erodible top coating above the delivery coating, the top coating adapted to delay the release of the delivery media from the delivery coating.
Dependencies are inferred from the claim text.