US 2008/0306308 A1Published application

Process for preparing fluorine-containing alkoxyalkane

OwnerTetsuo Nanno, Masaki Deguchiinventors

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Abstract

A process for preparing a fluorine-containing alkoxyalkane represented by the general formula (1) R1—O—R2—O—R3 where at least one of R1, R2 and R3 contains one or more fluorine atoms. An alcohol with the highest acidity selected from the group consisting of the compounds represented by the general formula (2) R1—OH, the general formula (3) R3—O—R2—OH, the general formula (4) R1—O—R2—OH, and the general formula (5) R3—OH is reacted with at least one selected from the group consisting of the compounds represented by the general formula (6) Lg-R2—O—R3, the general formula (7) Lg-R1, the general formula (8) Lg-R3, and the general formula (9) Lg-R2—O—R1 where Lg represents an anionic leaving group in the presence of a basic compound.

Claims14

Dependent claims

A process for preparing a fluorine-containing alkoxyalkane represented by the general formula (1):

R1—O—R2—O—R3 (1)
where each of R1 and R3 is a C1 to C6 alkyl group in which part of the hydrogen atoms may be replaced with one or more fluorine atoms, R2 is a C2 to C4 alkylene group in which part of the hydrogen atoms may be replaced with one or more fluorine atoms, and at least one of R1, R2 and R3 contains one or more fluorine atoms,
said process comprising the step of reacting a first compound with a second compound in a basic compound or a solvent containing a basic compound, said second compound being reactive with said first compound,
wherein said first compound is an alcohol with the highest acidity selected from the group consisting of the compounds represented by the general formulas (2) to (5):
R1—OH (2)
R3—O—R2—OH (3)
R1—O—R2—OH (4)
R3—OH (5)
said second compound is one selected from the group consisting of the compounds represented by the general formulas (6) to (9):
Lg-R2—O—R3 (6)
Lg-R1 (7)
Lg-R3 (8)
Lg-R2—O—R1 (9)
where Lg represents an anionic leaving group, and
said second compound is a compound that reacts with said first compound to yield said fluorine-containing alkoxyalkane.

12 more elements

A process for preparing a fluorine-containing alkoxyalkane represented by the general formula (10):

R5—O—R4—O—R5 (10)
where R4 is a C2 to C4 alkylene group in which part of the hydrogen atoms may be replaced with one or more fluorine atoms, R5 is a C1 to C6 alkyl group in which part of the hydrogen atoms may be replaced with one or more fluorine atoms, and at least one of R4 and R5 includes one or more fluorine atoms,
said process comprising the step of reacting a third compound with a fourth compound in a basic compound or a solvent containing a basic compound, said fourth compound being reactive with said third compound,
wherein said third compound is an alkoxide which is the conjugate base of an alcohol with a higher acidity selected from the group consisting of the compounds represented by the general formulas (11) and (12):
HO—R4—OH (11)
R5—OH (12),
said fourth compound is one selected from the group consisting of the compounds represented by the general formulas (13) and (14):
Lg-R5 (13)
Lg-R4-Lg′ (14)
where each of Lg and Lg′ is an anionic leaving group, and
said fourth compound is a compound that reacts with said third compound to yield said fluorine-containing alkoxyalkane.

8 more elements

Dependencies are inferred from the claim text.