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US 2008/0306278 A1Published application
Process
AssigneeSmithKline Beecham Corporation
InventorsJason William Beames Cooke, Bobby Neal Glover, Ronnie Maxwell Lawrence, Matthew Jude Sharp, Maria Fumiko Tymoschenko
Life of this patent
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Abstract
An improved process for preparing arylethanoldiamines is described. Compounds of this type are known to be useful as agonists at atypical beta-adrenoceptors (also known as beta-3-adrenoceptors).
Claims3
A compound of Formula (IV):
- wherein:
- R2 represents hydrogen or C1-6alkyl;
- R3 represents hydrogen or C1-6alkyl;
- L represents a leaving group;
- R4 represents a group (W):
- wherein A represents an aryl, pyridine, thiophene or furan;
- R5 represents cyano, tetrazol-5-yl or —CO2R8;
- R6 and R7 independently represent hydrogen, C1-6alkyl, —CO2R8, cyano, tetrazol-5-yl, halogen, trifluoromethyl or C1-6 alkoxy, or when R6 and R7 are bonded to adjacent carbon atoms, R6 and R7 may, together with the carbon atoms to which they are bonded, form a fused 5- or 6-membered ring optionally containing one or two nitrogen, oxygen or sulfur atoms;
- each R12 independently represents substituents selected from:
- C1-6alkyl, halogen, trifluoromethyl and C1-6alkoxy, and n represents an integer from 0-4;
- R8 and R9 independently represent C1-6alkyl;
- and
- R11 represents C1-6alkyl or aryl optionally substituted by C1-6alkyl or halogen.
10 more elements
Dependencies are inferred from the claim text.