One-pot methods for preparing cinnamide derivatives

A method for preparing a compound of the following formula (1) or a pharmaceutically acceptable salt thereof:

• wherein R represents a 6- to 14-membered aromatic hydrocarbon ring group or a 5- to 14-membered aromatic heterocyclic group, both of which may have a substituent;
• Q represents a single bond or —CH(Y)— wherein Y represents a hydrogen atom or an alkyl group having 1to 6 carbons;
• and n represents 0 to 2,
• comprises reacting a compound represented by the following formula (2):
• wherein R1 represents a 6- to 14-membered aromatic hydrocarbon ring group or a 5- to 14-membered aromatic heterocyclic group, both of which may have an appropriately protected substituent;
• and Q and n have the same meanings as described above,
• with 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde in the presence of a base and, if necessary, removing a protecting group.