Loading patent…
AssigneeNanjing University
InventorsYiqiao Hu, Jinhui Wu, Lin Wu, Lingying Luo, Feng Zhi
Estimating the term…
Conjugate of biomacromolecule with bioreductive which can be useful for treating tumor is provided. The biomacromolecule is selected from apo-transferrin, Fe-transferrin, Ru-transferrin, Ti-transferrin, Ga-transferrin, Pt-transferrin, somatostatin, EGF, folacin acid or transcobalamin, and the bioreductive agent is selected from quinones, aromatic nitrogen oxides, fatty nitrogen oxides, heterocyclic nitro compound, transition metal compound. Such conjugate can selectively target the tumor cells, and lower the toxicity of medicines and survivability of tumor cells, so that the conjugate can be used for delivery of anti-tumor compounds or treating tumors.
A conjugate comprising a biomacromolecule and a bioreductive agent, wherein said biomacromolecule is selected from the group consisting of apo-transferrin, Fe-transferrin, Ru-transferrin, Ti-transferrin, Ga-transferrin, Pt-transferrin, somatostatin, epidermal growth factor, folic acid and transcobalamin, and said bioreductive agent is selected from the group consisting of quinone, aromatic N-oxide, aliphatic N-oxide, nitroheterocyclic compound and transition-metal complexe, and wherein said homogeneous conjugates is substantially free of dimers, trimers and aggregates.
A method for making a conjugate comprising covalent binding and noncovalent binding, wherein said noncovalent binding is select from the group consisting of hydrogen bond, electrostaitic interaction and coordination.
Dependencies are inferred from the claim text.