Method for treating renal disease
OwnerRichard J. Roman, John R. Falckinventors
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Abstract
A method preserving renal medullary blood flow in a renal disorder in a human or non-human animal is disclosed. The method involves administering 20-HETE or a 20-HETE analog to the human or non-human animal in an amount sufficient to attenuate a fall in renal medullary blood flow following a renal disorder. In addition, a method for preventing and treating ischemic acute renal failure is disclosed. The method involves administering 20-HETE or a 20-HETE agonist to the human or non-human animal in an amount sufficient to prevent or treat ischemic acute renal failure.
Claims15
A method for preserving renal medullary blood flow caused by a renal disorder in a human or non-human animal comprising the step of:
- administering an agent selected from the group consisting of 20-HETE and a 20-HETE analog to the human or non-human animal in an amount sufficient to prevent to treat the renal disorder.
A method for treating ischemic acute renal failure in a human or non-human animal comprising the step of:
- administering a 20-HETE analog selected from the group consisting of N-methylsulfonyl-20-hydroxyeicosa-5(Z), 14(Z)-dienamide 5(Z), 14(Z) 20-hydroxyeicosadienoic acid (5,14-20-HEDE) and N-[20-hydroxyeicosa-5(Z), 14(Z)-dienoyl]glycine (5, 14-20-HEDGE) to the human or non-human animal in an amount sufficient to prevent or treat ischemic acute renal failure.
Dependencies are inferred from the claim text.