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AssigneeIDEXX Lboratories, Inc.
InventorsYerramilli V.S.N. Murthy, Robert H. Suva
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The present invention provides compositions and methods for administering florfenicol to mammals. The compositions contain a prodrug of florfenicol in a pharmaceutically acceptable carrier. In one embodiment the prodrug is an esterized form of florfenicol. Examples of suitable prodrugs include one or a combination of one or a combination of the following: florfenicol acetate, florfenicol propionate, florfenicol butyrate, florfenicol pentanoate, florfenicol hexanoate, florfenicol heptanoate, florfenicol octanoate, florfenicol nanoate, florfenicol decanoate, florfenicol undecanoate, florfenicol dodecanoate, and florfenicol phthalate. In another embodiment the prodrug is converted into the florfenicol in vivo by the action of one or more endogenous esterases. The invention also provides new compounds, pharmaceutical compositions containing the compounds, and methods for their administration.
1-24. (canceled)
A composition comprising a first ester prodrug of florfenicol, a second ester prodrug of florfenicol, and a pharmaceutically acceptable carrier, wherein the composition is formulated as a composition for administration to a mammal by injection.
A composition comprising (i) a first ester prodrug of florfenicol having a first release rate, (ii) a second ester prodrug of florfenicol have a second release rate, and (iii) a pharmaceutically acceptable carrier, wherein the composition is formulated for administration to a mammal by injection, the composition forms a drug depot when injected into the mammal, and the first release rate is different from the second release rate.
The composition of claim 1, wherein the first ester prodrug of florfenicol is florfenicol butyrate and the second ester prodrug of florfenicol is florfenicol hexanoate.
Dependencies are inferred from the claim text.