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US 2008/0306140 A1Published application
Isoflavonoid Dimers
AssigneeNovogen Research Pty. Ltd.
InventorsAndrew Heaton, Naresh Kumar
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Abstract
Novel compounds based on phenyl-substituted naphtho[1,2-g]chrysene compounds (A) are described. The compounds are obtainable by dimerisation of 3-phenylchroman (isoflavonoid) ring systems (B). Methods of synthesis of the novel dimeric compounds, compositions containing same and use of the dimers as therapeutic agents are also described.
Claims22
A compound of the general formula (I):
- wherein
- R1, R2, R3, R4, R5, R6, R7 and R8 are independently hydrogen, hydroxy, OR9, OC(O)H, OC(O)R9, OSi(R10)3, C(O)R11, CO2R12, alkyl, haloalkyl, cycloalkyl, aryl, arylalkyl, thiol, alkylthio, amino, alkylamino, dialkylamino, nitro, cyano or halo,
- R9 is alkyl, haloalkyl, aryl, arylalkyl or alkylaryl,
- R10 is independently hydrogen, alkyl or aryl,
- R11 is hydrogen alkyl, aryl, arylalkyl or an amino acid,
- R12 is hydrogen, alkyl, haloalkyl, aryl or arylalkyl, and
- X is O, NR12 or S, preferably O,
- which compounds may be optionally substituted or a pharmaceutically acceptable salt thereof.
5 more elements
17-21. (canceled)
(canceled)
(canceled)
Dependencies are inferred from the claim text.