Thalidomide analogs for treating vascular abnormalities
AssigneeCharlesson, LLC
InventorDanyang Chen
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Abstract
Thalidomide analog compounds having a general structure are described. R1 is selected from a group comprising of hydroxy, hydrogen, and amino. Also described is a method for treating vascular abnormalities, such as neovascularization and vascular leakage. A therapeutically effective amount of a composition containing the thalidomide analog compound is administered to a patient. The composition may further include agents, such as solubilizing agents, inert fillers, diluents, excipients, or flavoring agents.
Claims15
A compound represented by a general structure:
- wherein R1 is selected from a group comprising of hydroxy, hydrogen, and amino.
A composition for treating vascular abnormalities in a patient, said composition comprising a compound of a general structure:
- wherein R1 is selected from a group comprising of hydroxy, hydrogen, and amino.
A method for treating vascular abnormalities in a patient, said method comprising administering to the patient a therapeutically effective amount of a composition, wherein the composition includes a compound of a general structure:
- wherein R1 is selected from a group comprising of hydroxy, hydrogen, and amino.
A method for synthesizing a compound of a general structure:
- said method comprising providing (2,6-diisopropylphenyl)-5-amino-1H-isoindole-1,3-dione and refluxing the (2,6-diisopropylphenyl)-5-amino-1H-isoindole-1,3-dione with H2, Pd/C, and acetone.
A method for synthesizing a compound of a general structure:
- said method comprising providing 5-nitrophthalic anhydrides and 2,4-diisopropylaniline, refluxing 5-nitrophthalic anhydrides and 2,4-diisopropylaniline with acetic acid to form a (2,6-diisopropylphenyl)-5-amino-1H-isoindole-1,3-dione product, and refluxing the (2,6-diisopropylphenyl)-5-amino-1H-isoindole-1,3-dione product with H2, Pd/C, and acetone.
Dependencies are inferred from the claim text.