Compositions Comprising Addl Receptors, Related Compositions, and Related Methods

115:

• A method for treating an ADDL-related disease comprising administering to subject in need of treatment one or more compounds that antagonize the binding of ADDLs to one or more receptors, wherein the one or more receptors is selected from the group consisting of synGAP, proSAP2/Shank3, a metabotropic glutamate receptor, a kainate sub-type glutamate receptor, an AMPA sub-type glutamate receptor, a NMDA sub-type glutamate receptor, an integrin receptor, an adhesion receptor, a trophic factor receptor, a Trk receptor, erbB4, a trophin receptor, insulin receptor, insulin growth factor receptor, a GABA receptor, a sodium/potassium ATPase, CAM kinase II, PrP protein, a receptor protein tyrosine phosphatase alpha (RPTPα) protein, a somatostatin receptor, a cannabinoid receptor, a sigma receptor, and VIP/PACAL receptor.

The method of claim 115, wherein the ADDL-related disease is Alzheimer's disease (AD).

The method of claim 115, wherein the ADDL-related disease is mild cognitive impairment (MCI).

The method of claim 115, wherein the ADDL-related disease is Down's syndrome.

The method of claim 115, wherein the one or more compounds is CNQX or a pharmaceutically acceptable derivative of CNQX.

A method of screening for compounds which interfere with the binding of ADDLs to one or more receptors comprising:

• a) contacting tissue culture cells with ADDLs and one or more test compounds;
• and
• b) determining the effect of the one or more test compounds on the binding of the ADDLs to one or more receptors, wherein the one or more receptors is selected from the group consisting of synGAP, proSAP2/Shank3, a metabotropic glutamate receptor, a kainate sub-type glutamate receptor, an AMPA sub-type glutamate receptor, a NMDA sub-type glutamate receptor, an integrin receptor, an adhesion receptor, a trophic factor receptor, a Trk receptor, erbB4, a trophin receptor, insulin receptor, insulin growth factor receptor, a GABA receptor, a sodium/potassium ATPase, CAM kinase II, PrP protein, a receptor protein tyrosine phosphatase alpha (RPTPα) protein, a somatostatin receptor, a cannabinoid receptor, a sigma receptor, and VIP/PACAL receptor.

A method of identifying compounds which interfere with the binding of ADDL surrogates to one or more receptors comprising:

• a) contacting tissue culture cells with ADDL surrogates and one or more test compounds;
• and
• b) determining the effect of the one or more test compounds on the binding of the ADDL surrogates to one or more receptors so that compounds which interfere with the binding of ADDL surrogates to one or more receptors are identified.