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US 2008/0306052 A1Published application
3, 6-Dihydro-2-Oxo-6H-1,3,4,-Thiadiazine Derivatives
AssigneeMerck Patent Gesellschaft
InventorsOliver Schadt, Dieter Dorsch, Melanie Schultz, Andree Blaukat
Life of this patent
Estimating the term…
Abstract
Compounds of the formula I, in which R1, R2, Q and B have the meanings indicated in claim 1, are inhibitors of tyrosine kinases, in particular Met kinase, and can be employed, inter alia, for the treatment of tumours.
Claims24
Compounds of the formula I
- in which
- R1 denotes H, A, Hal, OH, OA, SH, SA, SOA, SO2A, NO2, NH2, NHA, NAA′, SO2NH2, SO2NHA, SO2NAA′, CONH2, CONHA, CONAA′, NACOA′, NASO2A′, COOH, COOA or CN,
- R2 denotes H, A, Hal, SO2NH2, SO2NHA, SO2NAA′, CONH2, CONHA, CONAA′, NACOA′, NASO2A′, COOH, COOA or CN,
- R1 and R2 together also denote methylenedioxy,
- B is absent, denotes NHCOCONH(CH2)nR3, NHCOCONA(CH2)nR3, NHCOCOO(CH2)nR3, OCONH(CH2)nR3, OCONA(CH2)nR3, NHCONH(CH2)nR3, NACONH(CH2)nR3, N(CH2)nR3, CONH(CH2)nR3, SO2NH(CH2)nR3, SO2NA(CH2)nR3, NHSO2(CH2)nR3 or NASO2(CH2)nR3,
- Q is absent or denotes alkylene having 1-4 C atoms,
- R3 denotes R1, Het or
- alkyl having 1-6 C atoms or cycloalkyl having 3-8 C atoms, each of which is unsubstituted or mono-, di-, tri- or tetrasubstituted by R4,
- R4 denotes A, Hal, OH, OA, SH, SA, SOA, SO2A, NO2, NH2, NHA, NAA′, SO2NH2, SO2NHA, SO2NAA′, CONH2, CONHA, CONAA′, NACOA′, NASO2A′, COOH, COOA or CN,
- Het denotes a mono- or bicyclic saturated heterocycle having 1 to 4 N, O and/or S atoms, which may be unsubstituted or mono-, di- or trisubstituted by R4, CHO, COA, ═S, ═NH, ═NA and/or ═O (carbonyl oxygen),
- A, A′ each, independently of one another, denote unbranched or branched alkyl having 1-10 C atoms,
- in which 1-7H atoms may be replaced by F, Cl and/or Br, cycloalkyl having 3-8 C atoms or cycloalkylalkylene having 4-10 C atoms,
- Hal denotes F, Cl, Br or I,
- n denotes 0, 1, 2 or 3,
- and pharmaceutically usable derivatives, solvates, salts, tautomers and stereoisomers thereof, including mixtures thereof in all ratios.
12 more elements
Dependencies are inferred from the claim text.