1-Benzazepine-3-Sulfonylamino-2-Pyrroridones as Factor Xa Inhibitors

A compound of formula (I):

• wherein:
• R1 represents a group selected from:
• each ring of which optionally contains a further heteroatom N,
• Z is an optional substituent halogen,
• alk is alkylene or alkenylene, and
• T represents S, O or NH;
• R2 is hydrogen, —C1-6alkyl, —C1-3alkylCONRaRb, —C1-3alkylCO2C1-4alkyl, —CO2C1-4alkyl, —C1-3alkylOH, —C1-3alkylOC1-3alkyl, or —C1-3alkylCO2H;
• Ra and Rb independently are hydrogen, —C1-6alkyl, or together with the N atom to which they are bonded form a 5-, 6- or 7-membered non-aromatic heterocyclic ring optionally containing an additional heteroatom selected from O, N and S, optionally substituted by C1-4 alkyl, and optionally the S heteroatom is substituted by S(O)n;
• n is 0-2;
• one of W, X and Y is —N(R6)— and the others are —CH(R7)—.
• R3, R4 and R5 independently are hydrogen, C1-4alkyl or halogen;
• R6 is hydrogen or C1-4alkyl;
• R7, R8 and R9 independently are hydrogen or C1-4alkyl;
• and pharmaceutically acceptable derivative(s) thereof.