Antibacterial amide macrocycles VII

A compound of formula

• in which
• R26 represents hydrogen, halogen, hydroxy or methyl,
• R7 represents a group of formula
• whereby
• R1 represents hydrogen or hydroxy,
• * is the linkage site to the carbon atom,
• R2 represents hydrogen or methyl,
• R3 represents a group of formula
• whereby
• * is the linkage site to the nitrogen atom,
• A represents a bond or phenyl,
• R4 represents hydrogen, amino or hydroxy,
• R5 represents a group of formula
• wherein
• * is the linkage site to the carbon atom,
• R23 represents hydrogen or a group of formula *-(CH2)n—OH or *-(CH2)o—NH2,
• wherein
• * is the linkage site to the carbon atom,
• n and o independently of one another are a number 1, 2, 3 or 4,
• m is a number 0 or 1,
• R8 and R12 independently of one another represent a group of formula *-CONHR14 or *-CH2CONHR15
• wherein
• * is the linkage site to the carbon atom,
• R14 and R15 independently of one another represent a group of formula
• wherein
• * is the linkage site to the nitrogen atom,
• R4a represents hydrogen, amino or hydroxy,
• R5a represents hydrogen, methyl or aminoethyl,
• R6a represents hydrogen or aminoethyl,
• or
• R5a and R6a together with the nitrogen atom to which they are bonded form a piperazine ring,
• R8a and R12a independently of one another represent *-(CH2)Z1a—OH, *-(CH2)Z2a—NHR13a, *-CONHR14a or *-CH2CONHR15a,
• wherein
• * is the linkage site to the carbon atom,
• Z1a and Z2a independently of one another are a number 1, 2 or 3,
• R13a represents hydrogen or methyl,
• and
• R14a and R15a independently of one another represent a group of formula
• wherein
• * is the linkage site to the nitrogen atom,
• R4c represents hydrogen, amino or hydroxy,
• R5c represents hydrogen, methyl or aminoethyl,
• R6c represents hydrogen or aminoethyl,
• kc is a number 0 or 1,
• and
• lC is a number 1, 2, 3 or 4,
• R9a and R11a independently of one another represent hydrogen or methyl,
• R10a represents amino or hydroxy,
• R16a represents a group of formula
• wherein
• * is the linkage site to the nitrogen atom,
• R4d represents hydrogen, amino or hydroxy,
• R5d represents hydrogen, methyl or aminoethyl,
• R6d represents hydrogen or aminoethyl,
• kd is a number 0 or 1,
• and
• ld is a number 1, 2, 3 or 4,
• ka is a number 0 or 1,
• and
• la, wa, xa and ya independently of one another are a number 1, 2, 3 or 4,
• R9 represents hydrogen, methyl, *-C(NH2)═NH or a group of formula
• wherein
• * is the linkage site to the nitrogen atom,
• R20 represents hydrogen or *-(CH2)i—NHR22,
• wherein
• R22 represents hydrogen or methyl,
• and
• i is a number 1, 2 or 3,
• R21 represents hydrogen or methyl,
• f is a number 0, 1, 2 or 3,
• g is a number 1, 2 or 3,
• and
• h is a number 1, 2, 3 or 4,
• R16 and R17 independently of one another represent a group of formula
• wherein
• * is the linkage site to the nitrogen atom,
• R4b represents hydrogen, amino or hydroxy,
• R5b represents hydrogen, methyl or aminoethyl,
• R6b represents hydrogen or aminoethyl,
• or
• R5b and R6b together with the nitrogen atom to which they are bonded form a piperazine ring,
• R8b and R12b independently of one another represent *-(CH2)Z1b—OH, *-(CH2)z2b—NHR13b, *-CONHR4b or *-CH2CONHR15b,
• wherein
• * is the linkage site to the carbon atom,
• R3b represents hydrogen or methyl,
• and
• Z1b and Z2b independently of one another are a number 1, 2 or 3,
• and
• R4b and R1b independently of one another represent a group of formula
• wherein
• * is the linkage site to the nitrogen atom,
• R4g represents hydrogen, amino or hydroxy,
• R5g represents hydrogen, methyl or aminoethyl,
• R6g represents hydrogen or aminoethyl,
• kg is a number 0 or 1,
• and
• lg is a number 1, 2, 3 or 4,
• R9b and R11b independently of one another represent hydrogen or methyl,
• R10b represents amino or hydroxy,
• kb is a number 0 or 1,
• lb, wb, xb and yb independently of one another are a number 1, 2, 3 or 4,
• R18 represents hydrogen, amino or hydroxy,
• R19 represents hydrogen, methyl or a group of formula
• wherein
• * is the linkage site to the nitrogen atom,
• R25 represents hydrogen or *-(CH2)u—NHR
• wherein
• R29 represents hydrogen or methyl,
• and
• u is a number 1, 2 or 3,
• R28 represents hydrogen or methyl,
• s is a number 0, 1, 2 or 3,
• and
• t is a number 1, 2 or 3,
• R24 represents hydrogen or aminoethyl,
• d is a number 1, 2 or 3,
• k and q independently of one another are a number 0 or 1,
• l, r, w and y independently of one another are a number 1, 2, 3 or 4,
• independently of one another may when w, r or y equals 3 carry a hydroxy group, or one of its salts, its solvates or the solvates of its salts.