Pharmaceutical Compositions and Method for Treating, Reducing, Ameliorating, Alleviating, or Preventing Dry Eye
OwnerJinzhong Zhang, Zhenze Hu +1inventors
InventorsJinzhong Zhang, Zhenze Hu, Keith Wayne Ward
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Abstract
A composition for treating, reducing, ameliorating, alleviating, or preventing a dry eye condition or an opthalmologic disorder that has an etiology in inflammation comprises an inhibitor of activity of poly(ADP-ribose) polymerase (“PARP”). The composition can also include a modulator of pro-inflammatory gene expression.
Claims41
A composition comprising an inhibitor of PARP activity in an amount effective for treating, reducing, ameliorating, alleviating, or preventing in a subject a dry eye condition or a condition that requires rewetting of the eye.
A method for treating, reducing, ameliorating, alleviating, or preventing a dry eye condition or an ophthalmic disorder, which has an etiology in inflammation, the method comprising:
- (a) providing a composition comprising a an inhibitor of PARP activity;
- and (b) administering to a subject an amount of the composition at a frequency sufficient to treat, reduce, ameliorate, alleviate, or prevent the dry eye condition or the ophthalmic disorder in the subject.
A method for preparing a composition that is suitable for the treatment, reduction, amelioration, alleviation, or prevention of a dry eye condition or a condition that requires the rewetting of the eye;
- the method comprising combining an inhibitor of PARP activity with a pharmaceutically acceptable carrier to form the composition.
Dependencies are inferred from the claim text.